First Case of a Cerebrocortical Ganglioglioma in a Dog

Laura Martín*, Martí Pumarola, Raúl Altuzarra, Javier Espinosa, María Ortega

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Gangliogliomas are extremely rare tumors of the nervous system composed of neoplastic glial and neuronal cells. The aim of the present paper is to describe the clinical presentation, magnetic resonance imaging (MRI) findings and histopathological and immunophenotypical characteristics of a cerebral cortex ganglioglioma in a 7-year-old Border Collie. The dog presented an acute onset of tonic-clonic epileptic seizures. MRI revealed a well-defined large intra-axial mass located on the left forebrain, mainly affecting the frontal cortex. Following humane euthanasia, the histopathological examination of the mass revealed a diffuse proliferation of neoplastic glial cells mixed with anomalous neuronal bodies. Immunohistochemical analyses confirmed the presence of two different populations of neoplastic cells. Most neoplastic glial cells were immunoreactive to glial fibrillary acidic protein (GFAP) and the other subset of neoplastic cells were positive to neuronal markers such as PGP 9.5, synaptophysin (SYN) and neuron-specific enolase (NSE), suggestive of neuronal cells. These findings confirmed the diagnosis of a cerebrocortical ganglioglioma. To the authors knowledge, this is the first description of a ganglioglioma of the cerebral cortex in a dog.

Original languageEnglish
Article number514
JournalVeterinary Sciences
Volume9
Issue number10
DOIs
Publication statusPublished - 21 Sep 2022

Keywords

  • canine
  • central nervous system
  • ganglioglioma
  • glial fibrillary acidic protein
  • neoplasia
  • neuron-specific enolase
  • synaptophysin
  • tumor

Fingerprint

Dive into the research topics of 'First Case of a Cerebrocortical Ganglioglioma in a Dog'. Together they form a unique fingerprint.

Cite this