Fighting neurodegeneration with rapamycin: Mechanistic insights

Jordi Bové, Marta Martínez-Vicente, Miquel Vila

Research output: Contribution to journalReview articleResearchpeer-review

330 Citations (Scopus)

Abstract

A growing number of studies point to rapamycin as a pharmacological compound that is able to provide neuroprotection in several experimental models of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and spinocerebellar ataxia type 3. In addition, rapamycin exerts strong anti-ageing effects in several species, including mammals. By inhibiting the activity of mammalian target of rapamycin (mTOR), rapamycin influences a variety of essential cellular processes, such as cell growth and proliferation, protein synthesis and autophagy. Here, we review the molecular mechanisms underlying the neuroprotective effects of rapamycin and discuss the therapeutic potential of this compound for neurodegenerative diseases. © 2011 Macmillan Publishers Limited. All rights reserved.
Original languageEnglish
Pages (from-to)437-452
JournalNature Reviews Neuroscience
Volume12
Issue number8
DOIs
Publication statusPublished - 1 Aug 2011

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