Fibromyalgia prevalence and related factors in a large registry of patients with systemic lupus erythematosus

Vicenç Torrente-Segarra, Tarek C. Salman-Monte, íñigo Rúa-Figueroa, Sabina Pérez-Vicente, Francisco J. López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Alejandro Olivé-Marqués, Jesus Ibáñez-Ruán, Loreto Horcada, Ana Sánchez-Atrio, Carlos Montilla, Manuel Rodríguez-Gómez, Elvira Díez-álvarez, Victor Martinez-Taboada, José L. Andreu, Olaia Fernández-Berrizbeitia, José A. Hernández-Beriain, Marian Gantes, Blanca Hernández-Cruzángela Pecondón-Español, Carlos Marras, Gema Bonilla, José M. Pego-Reigosa, Ricardo Blanco, Paloma Vela-Casasempere, Rafael Melero-González, Teresa Otón-Sánchez, Eva Tornero-Muriel, Esther Uriarte-Isacelaya, Mercedes Freire-González, María Concepción Fito-Manteca, Antonio Fernández-Nebro, Javier Narváez, Antonio Zea-Mendoza, José Carlos Rosas-Gómez de Salazar, Mónica Ibáñez-Barceló, José J. Pérez-Venegas, Inmaculada de la Torre Ortega, Luis Carreño Pérez, Patricia Carreira Delgado, Esther Rodríguez-Almaraz, Esteban Salas Heredia, Gregorio Santos Soler, Carlos Santos Ramírez, José M. Senabre Gallego, Mariano Andrés Collado, José Antonio Bernal, Inmaculada Ros Vilamajó, Antonio Juan Mas, Claudia Murillo, Ivan Castellví Barranco, Emma García Melchor, Joan Calvet Fontova, María García Manrique, Carlos Galisteo Lencastre, Mireia Moreno Martínez-Losa, Raúl Menor Almagro, Miguel A. González-Gay Mantecón, Inés Pérez Martíny, M. del Carmen Bejerano, Ignacio Villa Blanco, Begoña Moreira, Elena Aurrecoechea, Teresa Ruiz Jimeno, ángeles Aguirre Zamorano, César Magro, Enrique Raya álvarez, Celia Erausquin Arruabarrena, M. ángeles Acosta Mérida, Cesar A. Egües Dubuc, Jorge Cancio Fanlo, Elvira Díez álvarez, Carlos Vitovi, Alejandra López Robles, Tomás Vázquez Rodríguez, M. Victoria Irigoyen Oyarzábal, M. ángeles Belmonte López, Carmen M. Romero Barco, Juan Antonio Martínez López, Olga Sánchez Pernaute, Txaro García de Vicuña Pinedo, Marta Valero Expósito, Paloma García de la Peña, Silvia Rodríguez Rubio, Jorge J. González Martín, Ana Pérez Gómez, Cristina Bohórquez, Atusa Morasat Hajkhan, Ana I. Turrión Nieves, Ana J. Lois Iglesias, Aline Lucice Boteanu, M. Luz Gamir Gamir, Patricia Richi Alberti, Santiago Muñoz Fernández, María Rosario Oliva, Claudia Stoye, íñigo Hernández Rodríguez, Coral Mouriño Rodríguez, Bruno de Aspe de la Iglesia

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    34 Citations (Scopus)

    Abstract

    © Clinical and Experimental Rheumatology 2016. Objective. The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors. Methods. A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed. Inclusion criteria: patients who fulfilled =4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed. Results. 3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047. Conclusion. Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLErelated factors associated with FM.
    Original languageEnglish
    Pages (from-to)40-47
    JournalClinical and Experimental Rheumatology
    Volume34
    Publication statusPublished - 1 Jan 2016

    Keywords

    • Depression
    • Disease activity
    • Fibromyalgia
    • Systemic lupus erythematosus

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