TY - JOUR
T1 - Fibromyalgia prevalence and related factors in a large registry of patients with systemic lupus erythematosus
AU - Torrente-Segarra, Vicenç
AU - Salman-Monte, Tarek C.
AU - Rúa-Figueroa, íñigo
AU - Pérez-Vicente, Sabina
AU - López-Longo, Francisco J.
AU - Galindo-Izquierdo, María
AU - Calvo-Alén, Jaime
AU - Olivé-Marqués, Alejandro
AU - Ibáñez-Ruán, Jesus
AU - Horcada, Loreto
AU - Sánchez-Atrio, Ana
AU - Montilla, Carlos
AU - Rodríguez-Gómez, Manuel
AU - Díez-álvarez, Elvira
AU - Martinez-Taboada, Victor
AU - Andreu, José L.
AU - Fernández-Berrizbeitia, Olaia
AU - Hernández-Beriain, José A.
AU - Gantes, Marian
AU - Hernández-Cruz, Blanca
AU - Pecondón-Español, ángela
AU - Marras, Carlos
AU - Bonilla, Gema
AU - Pego-Reigosa, José M.
AU - Blanco, Ricardo
AU - Vela-Casasempere, Paloma
AU - Melero-González, Rafael
AU - Otón-Sánchez, Teresa
AU - Tornero-Muriel, Eva
AU - Uriarte-Isacelaya, Esther
AU - Freire-González, Mercedes
AU - Fito-Manteca, María Concepción
AU - Fernández-Nebro, Antonio
AU - Narváez, Javier
AU - Zea-Mendoza, Antonio
AU - Rosas-Gómez de Salazar, José Carlos
AU - Ibáñez-Barceló, Mónica
AU - Pérez-Venegas, José J.
AU - de la Torre Ortega, Inmaculada
AU - Pérez, Luis Carreño
AU - Delgado, Patricia Carreira
AU - Rodríguez-Almaraz, Esther
AU - Heredia, Esteban Salas
AU - Soler, Gregorio Santos
AU - Ramírez, Carlos Santos
AU - Senabre Gallego, José M.
AU - Collado, Mariano Andrés
AU - Bernal, José Antonio
AU - Vilamajó, Inmaculada Ros
AU - Mas, Antonio Juan
AU - Murillo, Claudia
AU - Barranco, Ivan Castellví
AU - Melchor, Emma García
AU - Fontova, Joan Calvet
AU - Manrique, María García
AU - Lencastre, Carlos Galisteo
AU - Martínez-Losa, Mireia Moreno
AU - Almagro, Raúl Menor
AU - González-Gay Mantecón, Miguel A.
AU - Martíny, Inés Pérez
AU - del Carmen Bejerano, M.
AU - Blanco, Ignacio Villa
AU - Moreira, Begoña
AU - Aurrecoechea, Elena
AU - Jimeno, Teresa Ruiz
AU - Zamorano, ángeles Aguirre
AU - Magro, César
AU - álvarez, Enrique Raya
AU - Arruabarrena, Celia Erausquin
AU - Mérida, M. ángeles Acosta
AU - Egües Dubuc, Cesar A.
AU - Fanlo, Jorge Cancio
AU - álvarez, Elvira Díez
AU - Vitovi, Carlos
AU - Robles, Alejandra López
AU - Rodríguez, Tomás Vázquez
AU - Oyarzábal, M. Victoria Irigoyen
AU - López, M. ángeles Belmonte
AU - Romero Barco, Carmen M.
AU - López, Juan Antonio Martínez
AU - Pernaute, Olga Sánchez
AU - de Vicuña Pinedo, Txaro García
AU - Expósito, Marta Valero
AU - de la Peña, Paloma García
AU - Rubio, Silvia Rodríguez
AU - González Martín, Jorge J.
AU - Gómez, Ana Pérez
AU - Bohórquez, Cristina
AU - Hajkhan, Atusa Morasat
AU - Turrión Nieves, Ana I.
AU - Lois Iglesias, Ana J.
AU - Boteanu, Aline Lucice
AU - Gamir, M. Luz Gamir
AU - Alberti, Patricia Richi
AU - Fernández, Santiago Muñoz
AU - Oliva, María Rosario
AU - Stoye, Claudia
AU - Rodríguez, íñigo Hernández
AU - Rodríguez, Coral Mouriño
AU - de Aspe de la Iglesia, Bruno
PY - 2016/1/1
Y1 - 2016/1/1
N2 - © Clinical and Experimental Rheumatology 2016. Objective. The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors. Methods. A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed. Inclusion criteria: patients who fulfilled =4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed. Results. 3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047. Conclusion. Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLErelated factors associated with FM.
AB - © Clinical and Experimental Rheumatology 2016. Objective. The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors. Methods. A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed. Inclusion criteria: patients who fulfilled =4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed. Results. 3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047. Conclusion. Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLErelated factors associated with FM.
KW - Depression
KW - Disease activity
KW - Fibromyalgia
KW - Systemic lupus erythematosus
M3 - Article
VL - 34
SP - 40
EP - 47
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
ER -