Fibrinolysis changes in normal pregnancy

Jordi Bellart, Rosa Gilabert, Jordi Fontcuberta, Montserrat Borrell, Ramon M. Miralles, Lluis Cabero

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34 Citations (Scopus)


The aim of this study was to evaluate the changes in fibrinolysis parameters during pregnancy. Normal pregnant women (n = 60) formed the study population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysis parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-1 and PAI-2) were determined. Tissue plasminogen activator and D-dimer increased after the first trimester and reached maximum levels during delivery. Plasminogen activator inhibitors type 1 and type 2 were also higher, in particular PAI-2, and reached maximum levels in the third trimester. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant range.
Original languageEnglish
Pages (from-to)368-372
JournalJournal of Perinatal Medicine
Issue number4
Publication statusPublished - 1 Jan 1997


  • D-dimer
  • Fibrinolysis
  • Plasminogen activator inhibitor
  • Pregnancy
  • Tissue plasminogen activator


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