Fibrinolysis changes in normal pregnancy

Jordi Bellart; Rosa Gilabert; Jordi Fontcuberta; Montserrat Borrell; Ramon M. Miralles; Lluis Cabero

doi:10.1515/jpme.1997.25.4.368

Fibrinolysis changes in normal pregnancy

Jordi Bellart, Rosa Gilabert, Jordi Fontcuberta, Montserrat Borrell, Ramon M. Miralles, Lluis Cabero

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Abstract

The aim of this study was to evaluate the changes in fibrinolysis parameters during pregnancy. Normal pregnant women (n = 60) formed the study population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysis parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-1 and PAI-2) were determined. Tissue plasminogen activator and D-dimer increased after the first trimester and reached maximum levels during delivery. Plasminogen activator inhibitors type 1 and type 2 were also higher, in particular PAI-2, and reached maximum levels in the third trimester. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant range.

Original language	English
Pages (from-to)	368-372
Journal	Journal of Perinatal Medicine
Volume	25
Issue number	4
DOIs	https://doi.org/10.1515/jpme.1997.25.4.368
Publication status	Published - 1 Jan 1997

Keywords

D-dimer
Fibrinolysis
Plasminogen activator inhibitor
Pregnancy
Tissue plasminogen activator

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10.1515/jpme.1997.25.4.368

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title = "Fibrinolysis changes in normal pregnancy",

abstract = "The aim of this study was to evaluate the changes in fibrinolysis parameters during pregnancy. Normal pregnant women (n = 60) formed the study population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysis parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-1 and PAI-2) were determined. Tissue plasminogen activator and D-dimer increased after the first trimester and reached maximum levels during delivery. Plasminogen activator inhibitors type 1 and type 2 were also higher, in particular PAI-2, and reached maximum levels in the third trimester. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant range.",

keywords = "D-dimer, Fibrinolysis, Plasminogen activator inhibitor, Pregnancy, Tissue plasminogen activator",

author = "Jordi Bellart and Rosa Gilabert and Jordi Fontcuberta and Montserrat Borrell and Miralles, {Ramon M.} and Lluis Cabero",

year = "1997",

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doi = "10.1515/jpme.1997.25.4.368",

language = "English",

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journal = "Journal of Perinatal Medicine",

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TY - JOUR

T1 - Fibrinolysis changes in normal pregnancy

AU - Bellart, Jordi

AU - Gilabert, Rosa

AU - Fontcuberta, Jordi

AU - Borrell, Montserrat

AU - Miralles, Ramon M.

AU - Cabero, Lluis

PY - 1997/1/1

Y1 - 1997/1/1

N2 - The aim of this study was to evaluate the changes in fibrinolysis parameters during pregnancy. Normal pregnant women (n = 60) formed the study population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysis parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-1 and PAI-2) were determined. Tissue plasminogen activator and D-dimer increased after the first trimester and reached maximum levels during delivery. Plasminogen activator inhibitors type 1 and type 2 were also higher, in particular PAI-2, and reached maximum levels in the third trimester. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant range.

AB - The aim of this study was to evaluate the changes in fibrinolysis parameters during pregnancy. Normal pregnant women (n = 60) formed the study population. Blood samples were taken in the first, second and third trimester, during delivery and three days after delivery. Fibrinolysis parameters were estimated using commercial tests. Tissue plasminogen activator, D-dimer and plasminogen activator inhibitors (PAI-1 and PAI-2) were determined. Tissue plasminogen activator and D-dimer increased after the first trimester and reached maximum levels during delivery. Plasminogen activator inhibitors type 1 and type 2 were also higher, in particular PAI-2, and reached maximum levels in the third trimester. On the third day after delivery, fibrinolysis activity recovered, but D-dimer and PAI-2 levels remained above the normal non-pregnant range.

KW - D-dimer

KW - Fibrinolysis

KW - Plasminogen activator inhibitor

KW - Pregnancy

KW - Tissue plasminogen activator

U2 - 10.1515/jpme.1997.25.4.368

DO - 10.1515/jpme.1997.25.4.368

M3 - Article

SN - 0300-5577

VL - 25

SP - 368

EP - 372

JO - Journal of Perinatal Medicine

JF - Journal of Perinatal Medicine

IS - 4

ER -

Fibrinolysis changes in normal pregnancy

Abstract

Keywords

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