FGF-2 low molecular weight selectively promotes neuritogenesis of motor neurons in vitro.

Ilary Allodi, Laura Casals-Díaz, Eva Santos-Nogueira, Francisco Gonzalez-Perez, Xavier Navarro, Esther Udina

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

In this study, we screened in vitro the different capabilities of trophic factors with promising effect for enhancing selective regeneration and thus promoting specific reinnervation of target organs after peripheral nerve regeneration. We found that FGF-2 (18 kDa) was the trophic factor that exerted the most selective effect in promoting neurite outgrowth of spinal motoneurons both in terms of elongation and arborization. The mechanism underlying this effect on neuritogenesis seems related to FGF-2 enhancing the interaction between FGFR-1 and PSA-NCAM. The interaction of these two receptors is important during the early stages of neuritogenesis and pathfinding, while integrin alpha7B subunit seems to play a role during neurite stabilization.
Original languageEnglish
Pages (from-to)770-781
JournalMolecular Neurobiology
Volume47
DOIs
Publication statusPublished - 1 Jan 2013

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