Fetoscopic coverage of experimental myelomeningocele in sheep using a patch with surgical sealant

Cesar G. Fontecha, Jose L. Peiro, Juan J. Sevilla, Marius Aguirre, Francisco Soldado, Laura Fresno, Carla Fonseca, Asiul Chacaltana, Vicente Martinez

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

Objective: Assess the feasibility of a fetoscopic patch coverage method for myelomeningocele repair in a sheep model. Study design: Experimental study. A myelomeningocele-like defect was created in 15 fetal sheep on day 75 of gestation. Six remained untreated, whereas 9 underwent fetoscopic coverage of the defect on day 95 of gestation using an inert patch secured with surgical sealant. Clinical and histological examinations were performed after delivery. Results: Four valid newborn lambs were obtained in each group. Mean fetoscopic surgical time was 26.9 (SD = 7.4) min. All untreated animals had an open lumbar defect with cerebrospinal fluid leakage, paraplegia, urinary incontinence, and Chiari malformation. All treated animals had a closed defect and were able to walk; one had weak bladder control, and another mild Chiari malformation. Conclusion: In a chronic myelomeningocele model in fetal sheep, fetoscopic repair using a sealed patch results in simple, fast, satisfactory neural tube closure and averts neurological damage and Chiari malformation. © 2011 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)171-176
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume156
Issue number2
DOIs
Publication statusPublished - 1 Jan 2011

Keywords

  • Fetal research
  • Fetoscopy
  • Myelomeningocele
  • Sheep

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