Fenofibrate: A new treatment for diabetic retinopathy. molecular mechanisms and future perspectives

Rafael Simó, Sayon Roy, Francine Behar-Cohen, Anthony Keech, Paul Mitchell, Tien Yin Wong

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Abstract

Despite improving standards of care, people with diabetes remain at risk of development and progression of diabetic retinopathy (DR) and visual impairment. Identifying novel therapeutic approaches, preferably targeting more than one pathogenic pathway in DR, and at an earlier stage of disease, is attractive. There is now consistent evidence from two major trials, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study and the Action to Control Cardiovascular Risk in Diabetes Eye (ACCORD-Eye) study, totalling 11,388 people with type 2 diabetes (5,701 treated with fenofibrate) that fenofibrate reduces the risk of development and progression of DR. Therefore, fenofibrate may be considered a preventive strategy for patients without DR or early intervention strategy for those with mild DR. A number of putative therapeutic mechanisms for fenofibrate, both dependent and independent of lipids, have been proposed. A deeper understanding of the mode of action of fenofibrate will further help to define how best to use fenofibrate clinically as an adjunct to current management of DR. © 2013 Bentham Science Publishers.
Original languageEnglish
Pages (from-to)3258-3266
JournalCurrent Medicinal Chemistry
Volume20
Issue number26
DOIs
Publication statusPublished - 1 Sep 2013

Keywords

  • Diabetic retinopathy
  • Fenofibrate
  • Mode of action
  • Pathogenesis
  • Type 2 diabetes

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