FeCl<inf>3</inf>-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives

Montserrat Pérez; Roser Pleixats

doi:10.1016/0040-4020(95)00446-F

FeCl<inf>3</inf>-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives

Montserrat Pérez, Roser Pleixats

Department of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

68 Citations (Scopus)

Abstract

β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis. © 1995 Elsevier Science Ltd.

Original language	English
Pages (from-to)	8355-8362
Journal	Tetrahedron
Volume	51
Issue number	30
DOIs	https://doi.org/10.1016/0040-4020(95)00446-F
Publication status	Published - 24 Jul 1995

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title = "FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives",

abstract = "β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis. {\textcopyright} 1995 Elsevier Science Ltd.",

author = "Montserrat P{\'e}rez and Roser Pleixats",

year = "1995",

month = jul,

day = "24",

doi = "10.1016/0040-4020(95)00446-F",

language = "English",

volume = "51",

pages = "8355--8362",

journal = "Tetrahedron",

issn = "0040-4020",

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FeCl<inf>3</inf>-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives. / Pérez, Montserrat; Pleixats, Roser.
In: Tetrahedron, Vol. 51, No. 30, 24.07.1995, p. 8355-8362.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - FeCl3-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives

AU - Pérez, Montserrat

AU - Pleixats, Roser

PY - 1995/7/24

Y1 - 1995/7/24

N2 - β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis. © 1995 Elsevier Science Ltd.

AB - β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis. © 1995 Elsevier Science Ltd.

U2 - 10.1016/0040-4020(95)00446-F

DO - 10.1016/0040-4020(95)00446-F

M3 - Article

SN - 0040-4020

VL - 51

SP - 8355

EP - 8362

JO - Tetrahedron

JF - Tetrahedron

IS - 30

ER -