FeCl<inf>3</inf>-catalyzed conjugate addition of secondary amines, imidazole and pyrazole to methyl 2-acetamidoacrylate. Preparation of β-dialkylamino-αalanine and β-(N-heteroaryi)-α-alanine derivatives

Montserrat Pérez, Roser Pleixats

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Abstract

β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives are obtained by conjugate addition of nitrogen based nuclcophiles (cyclic and acyclic secondary amines, imidazole and pirazole) to methyl 2-acetamidoacrylate, 1, under iron(III) chloride catalysis. © 1995 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)8355-8362
JournalTetrahedron
Volume51
Issue number30
DOIs
Publication statusPublished - 24 Jul 1995

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