Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome

María Carmona-Iragui, Telma Santos, Sebastián Videla, Susana Fernández, Bessy Benejam, Laura Videla, Daniel Alcolea, Kaj Blennow, Rafael Blesa, Alberto Lleó, Juan Fortea

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Abstract

© 2017 - IOS Press and the authors. All rights reserved. Background: Alzheimer's disease (AD) is the main medical problem in older adults with Down syndrome (DS). Studies of cerebrospinal fluid (CSF) AD biomarkers are limited and the feasibility of lumbar puncture (LP) is controversial in this population. Objective: To analyze the frequency of complications after a LP in DS. Methods: We collected data from 80 adults with DS that underwent a LP within the Down Alzheimer Barcelona Neuroimaging Initiative. Demographics, cognitive status, headache history, and presence of complications after the LP were recorded in every subject. In 53 of them (active group), this information was collected following a semi-structured and validated protocol that actively looks for complications. Other variables related to the LP procedure were also recorded. A telephone interview to the caregiver was performed 5-7 days after the procedure to ask about complications. Data from 27 subjects (clinical practice group), from whom the presence of complications was obtained in a medical follow-up visit within the three months after the LP, were also included. Results: There were no adverse events in 90 of our participants. The most frequent complication was headache (6.25); only one subject reported a typical post-lumbar puncture headache with moderate severity that required analgesic treatment. Dizziness (3.75) and back pain (1.25) were also reported. All the participants that reported complications belonged to the active group. Conclusion: LP can be safely performed to study CSF biomarkers in DS. The reported complications are qualitatively similar to the general population, but are less frequently reported, even when actively searched for.
Original languageEnglish
Pages (from-to)1489-1496
JournalJournal of Alzheimer's Disease
Volume55
Issue number4
DOIs
Publication statusPublished - 1 Jan 2017

Keywords

  • Alzheimer's disease
  • biomarkers
  • cerebrospinal fluid
  • complications
  • Down syndrome
  • lumbar puncture

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    Carmona-Iragui, M., Santos, T., Videla, S., Fernández, S., Benejam, B., Videla, L., Alcolea, D., Blennow, K., Blesa, R., Lleó, A., & Fortea, J. (2017). Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome. Journal of Alzheimer's Disease, 55(4), 1489-1496. https://doi.org/10.3233/JAD-160827