Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis

Joaquín Rullas, Juan Ignacio García, Manuela Beltrán, Pere Joan Cardona, Neus Cáceres, José Francisco García-Bustos, Iñigo Angulo-Barturen

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

Abstract

Murine models of Mycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Original languageEnglish
Pages (from-to)2262-2264
JournalAntimicrobial Agents and Chemotherapy
Volume54
Issue number5
DOIs
Publication statusPublished - 1 May 2010

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