TY - JOUR
T1 - Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis
AU - Rullas, Joaquín
AU - García, Juan Ignacio
AU - Beltrán, Manuela
AU - Cardona, Pere Joan
AU - Cáceres, Neus
AU - García-Bustos, José Francisco
AU - Angulo-Barturen, Iñigo
PY - 2010/5/1
Y1 - 2010/5/1
N2 - Murine models of Mycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
AB - Murine models of Mycobacterium tuberculosis infection are essential tools in drug discovery. Here we describe a fast standardized 9-day acute assay intended to measure the efficacy of drugs against M. tuberculosis growing in the lungs of immunocompetent mice. This assay is highly reproducible, allows good throughput, and was validated for drug lead optimization using isoniazid, rifampin, ethambutol, pyrazinamide, linezolid, and moxifloxacin. Copyright © 2010, American Society for Microbiology. All Rights Reserved.
U2 - 10.1128/AAC.01423-09
DO - 10.1128/AAC.01423-09
M3 - Article
SN - 0066-4804
VL - 54
SP - 2262
EP - 2264
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 5
ER -
