Fascicular nerve stimulation and recording using a novel double-aisle regenerative electrode

I. Delgado-Martínez, M. Righi, D. Santos, A. Cutrone, S. Bossi, S. D'Amico, J. Del Valle, S. Micera, X. Navarro

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)


© 2017 IOP Publishing Ltd. Objective. As artificial prostheses become more refined, they are most often used as a therapeutic option for hand amputation. By contrast to extra- or intraneural interfaces, regenerative nerve electrodes are designed to enable electrical interfaces with regrowing axonal bundles of injured nerves, aiming to achieve high selectivity for recording and stimulation. However, most of the developed designs pose an obstacle to the regrowth mechanisms due to low transparency and cause impairment to the nerve regeneration. Approach. Here we present the double-aisle electrode, a new type of highly transparent, non-obstructive regenerative electrode. Using a double-side thin-film polyimide planar multi-contact electrode, two nerve fascicles can regenerate without physical impairment through two electrically isolated aisles. Main results. We show that this electrode can be used to selectively record and stimulate fascicles, acutely as well as chronically, and allow regeneration in nerve gaps of several millimeters without impairment. Significance. This multi-aisle regenerative electrode may be suitable for neuroprosthetic applications, such as prostheses, for the restoration of hand function after amputation or severe nerve injuries.
Original languageEnglish
Article number046003
JournalJournal of Neural Engineering
Issue number4
Publication statusPublished - 12 May 2017


  • electrophysiology
  • nerve regeneration
  • neural interface
  • neuroprosthetic surgery
  • peripheral nerve
  • regenerative electrode
  • selectivity


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