Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time

Josephine M. Norquist; Crispin Jenkinson; Ray Fitzpatrick; Michael Swash; J. A. Aarli; J. M. Burgunder; T. Evangelista; R. Fitzpatrick; R. Genthon; O. Hardiman; I. Illa; Crispin Jenkinson; P. N. Leigh; H. P. Ludin; L. Mazzini; V. Meininger; J. S. Mora; M. Ortega; T. Papapetropoulos; V. Peto; D. Pongratz; J. Pouget; W. Robberecht; L. O. Ronnevi; M. Sales-Luis; V. Silani; M. Swash; J. H.J. Wokke; L. Werdelin; S. Zierz

doi:10.1080/14660820310004780

Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time

Josephine M. Norquist, Crispin Jenkinson, Ray Fitzpatrick, Michael Swash, J. A. Aarli, J. M. Burgunder, T. Evangelista, R. Fitzpatrick, R. Genthon, O. Hardiman, I. Illa, Crispin Jenkinson, P. N. Leigh, H. P. Ludin, L. Mazzini, V. Meininger, J. S. Mora, M. Ortega, T. Papapetropoulos, V. PetoD. Pongratz, J. Pouget, W. Robberecht, L. O. Ronnevi, M. Sales-Luis, V. Silani, M. Swash, J. H.J. Wokke, L. Werdelin, S. Zierz

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Abstract

Objectives: To determine which factors are predictive of physical and mental health one year after a first measurement of health status in amyotrophic lateral sclerosis (ALS) patients. Methods: The Physical Component Summary (PCS) score and the Mental Component Summary (MCS) score of the SF-36 were used as the main outcome measures in patients enrolled in the European ALS Health Profile Study (ALS-HPS). Correlation and stepwise regression procedures were used to determine the relationship between patients' physical and mental health status at follow-up with baseline measures. Results: A total of 1118 patients were recruited into the ALS-HPS, of which 918 (82.11%) returned fully or partially completed baseline and follow-up surveys. PCS scores declined over time. No significant changes were reported for the MCS scores over time for patients with ALS. Baseline scores were found to be significant predictors of patients' health status over time. Conclusions: Overall, patients' physical health status at the time of recruitment was the major predictor of the physical health status at both first and second follow-up time assessments. The same relationship was found between baseline and follow-up mental health status. The study also confirms the appropriateness of the use of the SF-36 in ALS patients.

Original language	English
Pages (from-to)	112-117
Journal	Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders
Volume	4
Issue number	2
DOIs	https://doi.org/10.1080/14660820310004780
Publication status	Published - 1 Jan 2003

Keywords

Amyotrophic lateral sclerosis
Health status measurement
SF-36

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14660820310004780

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Norquist, J. M., Jenkinson, C., Fitzpatrick, R., Swash, M., Aarli, J. A., Burgunder, J. M., Evangelista, T., Fitzpatrick, R., Genthon, R., Hardiman, O., Illa, I., Jenkinson, C., Leigh, P. N., Ludin, H. P., Mazzini, L., Meininger, V., Mora, J. S., Ortega, M., Papapetropoulos, T., ... Zierz, S. (2003). Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, 4(2), 112-117. https://doi.org/10.1080/14660820310004780

@article{8ccc0ca93198439998c8331b7c3bed31,

title = "Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time",

abstract = "Objectives: To determine which factors are predictive of physical and mental health one year after a first measurement of health status in amyotrophic lateral sclerosis (ALS) patients. Methods: The Physical Component Summary (PCS) score and the Mental Component Summary (MCS) score of the SF-36 were used as the main outcome measures in patients enrolled in the European ALS Health Profile Study (ALS-HPS). Correlation and stepwise regression procedures were used to determine the relationship between patients' physical and mental health status at follow-up with baseline measures. Results: A total of 1118 patients were recruited into the ALS-HPS, of which 918 (82.11%) returned fully or partially completed baseline and follow-up surveys. PCS scores declined over time. No significant changes were reported for the MCS scores over time for patients with ALS. Baseline scores were found to be significant predictors of patients' health status over time. Conclusions: Overall, patients' physical health status at the time of recruitment was the major predictor of the physical health status at both first and second follow-up time assessments. The same relationship was found between baseline and follow-up mental health status. The study also confirms the appropriateness of the use of the SF-36 in ALS patients.",

keywords = "Amyotrophic lateral sclerosis, Health status measurement, SF-36",

author = "Norquist, {Josephine M.} and Crispin Jenkinson and Ray Fitzpatrick and Michael Swash and Aarli, {J. A.} and Burgunder, {J. M.} and T. Evangelista and R. Fitzpatrick and R. Genthon and O. Hardiman and I. Illa and Crispin Jenkinson and Leigh, {P. N.} and Ludin, {H. P.} and L. Mazzini and V. Meininger and Mora, {J. S.} and M. Ortega and T. Papapetropoulos and V. Peto and D. Pongratz and J. Pouget and W. Robberecht and Ronnevi, {L. O.} and M. Sales-Luis and V. Silani and M. Swash and Wokke, {J. H.J.} and L. Werdelin and S. Zierz",

year = "2003",

month = jan,

day = "1",

doi = "10.1080/14660820310004780",

language = "English",

volume = "4",

pages = "112--117",

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Norquist, JM, Jenkinson, C, Fitzpatrick, R, Swash, M, Aarli, JA, Burgunder, JM, Evangelista, T, Fitzpatrick, R, Genthon, R, Hardiman, O, Illa, I, Jenkinson, C, Leigh, PN, Ludin, HP, Mazzini, L, Meininger, V, Mora, JS, Ortega, M, Papapetropoulos, T, Peto, V, Pongratz, D, Pouget, J, Robberecht, W, Ronnevi, LO, Sales-Luis, M, Silani, V, Swash, M, Wokke, JHJ, Werdelin, L & Zierz, S 2003, 'Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time', Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, vol. 4, no. 2, pp. 112-117. https://doi.org/10.1080/14660820310004780

Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time. / Norquist, Josephine M.; Jenkinson, Crispin; Fitzpatrick, Ray et al.

In: Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders, Vol. 4, No. 2, 01.01.2003, p. 112-117.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time

AU - Norquist, Josephine M.

AU - Jenkinson, Crispin

AU - Fitzpatrick, Ray

AU - Swash, Michael

AU - Aarli, J. A.

AU - Burgunder, J. M.

AU - Evangelista, T.

AU - Fitzpatrick, R.

AU - Genthon, R.

AU - Hardiman, O.

AU - Illa, I.

AU - Jenkinson, Crispin

AU - Leigh, P. N.

AU - Ludin, H. P.

AU - Mazzini, L.

AU - Meininger, V.

AU - Mora, J. S.

AU - Ortega, M.

AU - Papapetropoulos, T.

AU - Peto, V.

AU - Pongratz, D.

AU - Pouget, J.

AU - Robberecht, W.

AU - Ronnevi, L. O.

AU - Sales-Luis, M.

AU - Silani, V.

AU - Swash, M.

AU - Wokke, J. H.J.

AU - Werdelin, L.

AU - Zierz, S.

PY - 2003/1/1

Y1 - 2003/1/1

N2 - Objectives: To determine which factors are predictive of physical and mental health one year after a first measurement of health status in amyotrophic lateral sclerosis (ALS) patients. Methods: The Physical Component Summary (PCS) score and the Mental Component Summary (MCS) score of the SF-36 were used as the main outcome measures in patients enrolled in the European ALS Health Profile Study (ALS-HPS). Correlation and stepwise regression procedures were used to determine the relationship between patients' physical and mental health status at follow-up with baseline measures. Results: A total of 1118 patients were recruited into the ALS-HPS, of which 918 (82.11%) returned fully or partially completed baseline and follow-up surveys. PCS scores declined over time. No significant changes were reported for the MCS scores over time for patients with ALS. Baseline scores were found to be significant predictors of patients' health status over time. Conclusions: Overall, patients' physical health status at the time of recruitment was the major predictor of the physical health status at both first and second follow-up time assessments. The same relationship was found between baseline and follow-up mental health status. The study also confirms the appropriateness of the use of the SF-36 in ALS patients.

AB - Objectives: To determine which factors are predictive of physical and mental health one year after a first measurement of health status in amyotrophic lateral sclerosis (ALS) patients. Methods: The Physical Component Summary (PCS) score and the Mental Component Summary (MCS) score of the SF-36 were used as the main outcome measures in patients enrolled in the European ALS Health Profile Study (ALS-HPS). Correlation and stepwise regression procedures were used to determine the relationship between patients' physical and mental health status at follow-up with baseline measures. Results: A total of 1118 patients were recruited into the ALS-HPS, of which 918 (82.11%) returned fully or partially completed baseline and follow-up surveys. PCS scores declined over time. No significant changes were reported for the MCS scores over time for patients with ALS. Baseline scores were found to be significant predictors of patients' health status over time. Conclusions: Overall, patients' physical health status at the time of recruitment was the major predictor of the physical health status at both first and second follow-up time assessments. The same relationship was found between baseline and follow-up mental health status. The study also confirms the appropriateness of the use of the SF-36 in ALS patients.

KW - Amyotrophic lateral sclerosis

KW - Health status measurement

KW - SF-36

U2 - 10.1080/14660820310004780

DO - 10.1080/14660820310004780

M3 - Article

VL - 4

SP - 112

EP - 117

IS - 2

ER -

Factors which predict physical and mental health status in patients with amyotrophic lateral sclerosis over time

Abstract

Keywords

UN SDGs

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