Factors associated with the variability in caregiver assessments of the capacities of patients with alzheimer disease

Josep L. Conde-Sala, Ramón Reñé-Ramírez, Oriol Turró-Garriga, Jordi Gascón-Bayarri, Montserrat Juncadella-Puig, Laura Moreno-Cordón, Vanesa Viñas-Diez, Joan Vilalta-Franch, Josep Garre-Olmo

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    40 Citations (Scopus)


    Background: Several studies have identified certain caregiver factors that can produce variability in their assessments of the capacities of patients with Alzheimer disease (AD). Objectives: To identify the caregiver variables associated with variability in their ratings of patients' capacities. Methods: Consecutive sample of 221 outpatients with AD and their family caregivers. The capacities evaluated by caregivers were the degree of functional disability, using the Disability Assessment for Dementia (DAD); psychological and behavioral symptoms, via the Neuropsychiatric Inventory (NPI); anosognosia, with the Anosognosia Questionnaire-Dementia (AQ-D); and quality of life, using the Quality of Life in AD (QOL-AD). The relationship between these measures and caregiver's gender, burden, depression, and health was analyzed by means of a bivariate analysis, calculating the effect size (Cohen d) and subsequently by a regression analysis, calculating the contribution coefficient (CC). Results: The greatest variability in caregiver assessments was observed in relation to patients with early-stage dementia, where caregiver's burden was the main factor associated with a more negative evaluation (d = 1.02-1.25). Depression in the caregiver was associated with less variability and only in the assessments of patients with moderate dementia (d = 0.38-0.69). In the regression analysis, caregiver factors were associated with greater variance in scores on the NPI (CC = 37.4%) and QOL-AD (CC = 27.2%), and lower variance in AQ-D (CC = 21.6%) and DAD (CC = 10.3%) scores. Conclusions: Caregiver's burden and depression were associated with more negative assessments of patients' psychological and behavioral symptoms and quality of life. © The Author(s) 2013.
    Original languageEnglish
    Pages (from-to)86-94
    JournalJournal of Geriatric Psychiatry and Neurology
    Issue number2
    Publication statusPublished - 1 Jun 2013


    • Alzheimer disease
    • Anosognosia
    • Family caregivers
    • Functional capacity
    • Neuropsychiatric symptoms
    • Quality of life


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