TY - JOUR
T1 - Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine
AU - Saiz-Satjes, Margarita
AU - Martinez-Martin, Francisco Javier
AU - Roca-Cusachs, Alex
PY - 2017/3/1
Y1 - 2017/3/1
N2 - © 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
AB - © 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
KW - amlodipine
KW - diabetes
KW - hypertension
KW - manidipine
KW - microalbuminuria
U2 - 10.2217/fca-2016-0046
DO - 10.2217/fca-2016-0046
M3 - Article
VL - 13
SP - 143
EP - 151
JO - Future Cardiology
JF - Future Cardiology
SN - 1479-6678
IS - 2
ER -