Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine

Margarita Saiz-Satjes, Francisco Javier Martinez-Martin, Alex Roca-Cusachs

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

© 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
Original languageEnglish
Pages (from-to)143-151
JournalFuture Cardiology
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Mar 2017

Keywords

  • amlodipine
  • diabetes
  • hypertension
  • manidipine
  • microalbuminuria

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