Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine

Margarita Saiz-Satjes; Francisco Javier Martinez-Martin; Alex Roca-Cusachs

doi:10.2217/fca-2016-0046

Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine

Margarita Saiz-Satjes, Francisco Javier Martinez-Martin, Alex Roca-Cusachs

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

© 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.

Original language	English
Pages (from-to)	143-151
Journal	Future Cardiology
Volume	13
Issue number	2
DOIs	https://doi.org/10.2217/fca-2016-0046
Publication status	Published - 1 Mar 2017

Keywords

amlodipine
diabetes
hypertension
manidipine
microalbuminuria

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title = "Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine",

abstract = "{\textcopyright} 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.",

keywords = "amlodipine, diabetes, hypertension, manidipine, microalbuminuria",

author = "Margarita Saiz-Satjes and Martinez-Martin, {Francisco Javier} and Alex Roca-Cusachs",

year = "2017",

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doi = "10.2217/fca-2016-0046",

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Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine. / Saiz-Satjes, Margarita; Martinez-Martin, Francisco Javier; Roca-Cusachs, Alex.

In: Future Cardiology, Vol. 13, No. 2, 01.03.2017, p. 143-151.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Factors associated with the reduction of albumin excretion in diabetic hypertensive patients: Differential effect of manidipine versus amlodipine

AU - Saiz-Satjes, Margarita

AU - Martinez-Martin, Francisco Javier

AU - Roca-Cusachs, Alex

PY - 2017/3/1

Y1 - 2017/3/1

N2 - © 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.

AB - © 2016 Future Medicine Ltd. Aims: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. Methods: For this purpose, a multivariable analysis was performed. Results: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. Conclusion: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.

KW - amlodipine

KW - diabetes

KW - hypertension

KW - manidipine

KW - microalbuminuria

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DO - 10.2217/fca-2016-0046

M3 - Article

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EP - 151

JO - Future Cardiology

JF - Future Cardiology

SN - 1479-6678

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