Factors associated with poor functional outcome in bipolar disorder: sociodemographic, clinical, and neurocognitive variables

J. Sanchez-Moreno, C. M. Bonnin, A. González-Pinto, B. L. Amann, B. Solé, V. Balanzá-Martinez, C. Arango, E. Jiménez, R. Tabarés-Seisdedos, M. P. Garcia-Portilla, A. Ibáñez, J. M. Crespo, J. L. Ayuso-Mateos, A. Martinez-Aran, C. Torrent, E. Vieta, Analucía Alegría, Susana Al-Halabi, Silvia Alonso-Lana, Celia AnayaPurificación López, Julio Bobes, Guadalupe Chiclana, Esther Cerrillo, Patricia Correa, Núria Custal, Patricia Fernández, Sainza García, Inmaculada Fuentes-Durá, Gonzalo Galván, Itxaso González-Ortega, Sandra Isella, Ramon Landín-Romero, Manuel Menchón, Jessica Merchan-Naranjo, Jordi Ortiz-Gil, Isabella Pacchiarotti, Raquel Reyes, Marta Rapado-Castro, Maria Reinares, Maria Rodao, Pilar A. Saiz, Bárbara Segura, Gabriel Selva-Vera, Jerónimo Saiz-Ruiz, Virginia Soria, Iñaki Zorrilla, Jesús Valle, Elia Valls, Cristina Varo

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Objective: The current investigation aimed at studying the sociodemographic, clinical, and neuropsychological variables related to functional outcome in a sample of euthymic patients with bipolar disorder(BD) presenting moderate-severe levels of functional impairment. Methods: Two-hundred and thirty-nine participants with BD disorders and with Functioning Assessment Short Test(FAST) scores equal or above 18 were administered a clinical and diagnostic interview, and the administration of mood measure scales and a comprehensive neuropsychological battery. Analyses involved preliminary Pearson bivariate correlations to identify sociodemographic and clinical variables associated with the FAST total score. Regarding neuropsychological variables, a principal component analysis (PCA) was performed to group the variables in orthogonal factors. Finally, a hierarchical multiple regression was run. Results: The best fitting model for the variables associated with functioning was a linear combination of gender, age, estimated IQ, Hamilton Depression Rating Scale (HAM-D), number of previous manic episodes, Factor 1 and Factor 2 extracted from the PCA. The model, including all these previous variables, explained up to 29.4% of the observed variance. Conclusions: Male gender, older age, lower premorbid IQ, subdepressive symptoms, higher number of manic episodes, and lower performance in verbal memory, working memory, verbal fluency, and processing speed were associated with lower functioning in patients with BD.
Original languageEnglish
Pages (from-to)145-154
JournalActa Psychiatrica Scandinavica
Volume138
Issue number2
DOIs
Publication statusPublished - 1 Aug 2018

Keywords

  • bipolar disorder
  • depressive symptoms
  • functional impairment
  • neurocognition

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