TY - JOUR
T1 - Factors associated with depression and severe depression in patients with COPD
AU - Miravitlles, Marc
AU - Molina, Jesús
AU - Quintano, José Antonio
AU - Campuzano, Anna
AU - Pérez, Joselín
AU - Roncero, Carlos
PY - 2014/1/1
Y1 - 2014/1/1
N2 - © 2014 Elsevier Ltd. All rights reserved. SummaryBackground Depression is very prevalent in COPD and may be associated with poor clinical outcomes. Method This was a multicenter, cross-sectional study aimed at evaluating the prevalence of depression and moderate to severe depression in COPD. Depressive symptoms were evaluated with the Beck's Depression Inventory. The COPD assessment test (CAT) and the EuroQoL-5 dimensions (EQ-5D) questionnaires were used to evaluate health-related quality of life (HRQoL). Severity of COPD was assessed with the BODEx index and physical activity was estimated by the mean self-declared time walked per day. Results A total of 836 patients were included and up to 74.6% had some degree of depression with 51.5% having moderate to severe depression. On multivariate analysis, moderate to severe depression was associated with suicidal ideation (OR, 6.12; 95% confidence interval (CI), 1.36-28.24), worse quality of life: EQ-5D (OR, 0.89; 95%CI, 0.86-0.93) and worse CAT scores (OR, 1.32; 95%CI, 1.19-1.46). When questionnaires were not included in the analysis, significant depression was associated with the Charlson comorbidity index, minutes walked per day and BODEx score. Conclusions Depression is frequent in COPD and is associated with suicidal ideation, impaired HRQoL, increase in comorbidities, a reduction in physical activity and increased severity of COPD measured by the BODEx index.
AB - © 2014 Elsevier Ltd. All rights reserved. SummaryBackground Depression is very prevalent in COPD and may be associated with poor clinical outcomes. Method This was a multicenter, cross-sectional study aimed at evaluating the prevalence of depression and moderate to severe depression in COPD. Depressive symptoms were evaluated with the Beck's Depression Inventory. The COPD assessment test (CAT) and the EuroQoL-5 dimensions (EQ-5D) questionnaires were used to evaluate health-related quality of life (HRQoL). Severity of COPD was assessed with the BODEx index and physical activity was estimated by the mean self-declared time walked per day. Results A total of 836 patients were included and up to 74.6% had some degree of depression with 51.5% having moderate to severe depression. On multivariate analysis, moderate to severe depression was associated with suicidal ideation (OR, 6.12; 95% confidence interval (CI), 1.36-28.24), worse quality of life: EQ-5D (OR, 0.89; 95%CI, 0.86-0.93) and worse CAT scores (OR, 1.32; 95%CI, 1.19-1.46). When questionnaires were not included in the analysis, significant depression was associated with the Charlson comorbidity index, minutes walked per day and BODEx score. Conclusions Depression is frequent in COPD and is associated with suicidal ideation, impaired HRQoL, increase in comorbidities, a reduction in physical activity and increased severity of COPD measured by the BODEx index.
KW - Beck's depression inventory
KW - COPD
KW - Depression
KW - Physical activity
KW - Quality of life
U2 - 10.1016/j.rmed.2014.08.010
DO - 10.1016/j.rmed.2014.08.010
M3 - Article
VL - 108
SP - 1615
EP - 1625
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 11
ER -