Factors associated with adherence to guidelines for the use of tigecycline in a tertiary care hospital

Santiago Grau, D. Conde-Estévez, S. Luque, F. Álvarez-Lerma, J. P. Horcajada, J. Mateu-De Antonio, N. Berenguer, E. Salas

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We assessed the adherence to the prescribing hospital protocol for tigecycline and factors associated with non-compliance. A total of 103 patients were included in the study. In 23 (22.3%) patients, tigecycline was not administered according to the protocol, mostly because of the availability of other therapeutic alternatives and prescription for indications that were not included in the guidelines. Factors independently associated with non-adherence to the protocol were community-acquired infection (OR, 14.01; 95% CI, 1.54-127.12; P=0.019), and empirical tigecycline treatment (OR, 6.97; 95% CI, 0.88-55.40; P=0.066). Penicillin allergy (OR, 0.004; 95% CI, 0.000-0.071; P=0.001) and previous antibiotic treatment (OR, 0.025; 95% CI, 0.003-0.233; P=0.001) were factors associated with adherence to the hospital protocol. A positive time trend between total number of prescriptions and non-compliant prescriptions with the protocol was observed (Spearman's rho coefficient 0.971; P=0.001). Adherence to tigecycline protocol could be improved by focusing on protocols for community-acquired infections, mainly skin and soft tissue infections. © E.S.I.F.T. srl.
Original languageEnglish
Pages (from-to)339-344
JournalJournal of Chemotherapy
Issue number5
Publication statusPublished - 1 Jan 2010


  • Antibiotic usage
  • Antimicrobial stewardship
  • Audit
  • Protocol
  • Tigecycline


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