Facilitatory action of adrenergic drugs on muscle twitch evoked by nerve stimulation in the curarized rat phrenic hemidiaphragm

Albert Badia Sancho, Josep Eladi Banos Diez, Francesc Jane Carrenca

    Research output: Contribution to journalArticleResearchpeer-review

    16 Citations (Scopus)

    Abstract

    The facilitatory effects of α-adrenergic drugs on neuromuscular transmission has been studied in the curarized rat phrenic-hemidiaphragm. The reversal effect of blocking action of (+)-tubocurarine on indirectly-induced twitch by α-adrenergic agents was higher with noradrenaline (EC50 = 6.51 ± 0.18 μM) compared with adrenaline (EC50 = 11.80 ± 1.06 μM) or phenylephrine (EC50 = 17.36 ± 1.02 μM). Methoxamine, clonidine and azepexol showed no effect. The action of noradrenaline was blocked by prazosin (IC50 = 3.96 ± 0.76 nM) and tolazoline (IC50 = 10.30 ± 0.5 nM) but not by yohimbine at the concentration range 0.01-0.1 μM. From these results it could be concluded that an α1-adrenergic mechanism might be involved in the facilitatory action of α-adrenergic agents at the level of motor nerve terminals.
    Original languageEnglish
    Pages (from-to)219-227
    JournalArchives Internationales de Pharmacodynamie et de Therapie
    Volume293
    Issue number1
    Publication statusPublished - 1 Jan 1988

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