Extracellular vesicles: Squeezing every drop of regenerative potential of umbilical cord blood

Santiago Roura, Joaquim Vives

    Research output: Contribution to journalArticleResearch

    4 Citations (Scopus)

    Abstract

    © 2019 Elsevier Inc. Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which include a heterogeneous pool of membranous structures secreted by the vast majority of cells, can serve as powerful tools for cell-free therapy due to precise multifunctional molecular cargoes. In this issue, Hu et al. [1]described that EV extracted from UCB (UCB-EV)ameliorate bone loss in senile osteoporotic mice and promote in vitro osteoblast differentiation of bone marrow-derived Mesenchymal Stromal Cells through miR-3960-mediated signaling. These results envision the capability of UCB-EV of priming multipotent stem cells toward the osteogenic cell lineage and interfering on bone resorption processes. Although processing and manufacturing of EV-based products have to further develop major issues, we foresee that EV will soon become new therapeutic products supplied by UCB banks for treating human diseases, including bone-related conditions.
    Original languageEnglish
    Pages (from-to)102-104
    JournalMetabolism: Clinical and Experimental
    Volume95
    DOIs
    Publication statusPublished - 1 Jun 2019

    Keywords

    • Bone formation
    • Cell-free therapy
    • Extracellular vesicles
    • Osteogenesis
    • Regenerative medicine
    • Umbilical cord blood

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