Abstract
© 2019 Elsevier Inc. Collection, cryopreservation and transplantation of umbilical cord blood (UCB)-derived cells have become a popular option for regenerative medicine, not limited to the transplantation of hematopoietic cell progenitors only. Indeed, increasing evidence shows that extracellular vesicles (EV), which include a heterogeneous pool of membranous structures secreted by the vast majority of cells, can serve as powerful tools for cell-free therapy due to precise multifunctional molecular cargoes. In this issue, Hu et al. [1]described that EV extracted from UCB (UCB-EV)ameliorate bone loss in senile osteoporotic mice and promote in vitro osteoblast differentiation of bone marrow-derived Mesenchymal Stromal Cells through miR-3960-mediated signaling. These results envision the capability of UCB-EV of priming multipotent stem cells toward the osteogenic cell lineage and interfering on bone resorption processes. Although processing and manufacturing of EV-based products have to further develop major issues, we foresee that EV will soon become new therapeutic products supplied by UCB banks for treating human diseases, including bone-related conditions.
Original language | English |
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Pages (from-to) | 102-104 |
Journal | Metabolism: Clinical and Experimental |
Volume | 95 |
DOIs | |
Publication status | Published - 1 Jun 2019 |
Keywords
- Bone formation
- Cell-free therapy
- Extracellular vesicles
- Osteogenesis
- Regenerative medicine
- Umbilical cord blood