TY - JOUR
T1 - External validation of de novo stress urinary incontinence prediction model after vaginal prolapse surgery
AU - Sabadell, Jordi
AU - Salicrú, Sabina
AU - Montero-Armengol, Anabel
AU - Rodriguez-Mias, Núria
AU - Gil-Moreno, Antonio
AU - Poza, Jose L.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - © 2018, The International Urogynecological Association. Introduction and hypothesis: Stress urinary incontinence (SUI) may appear after the correction of pelvic organ prolapse (POP). The aim of this study was to externally validate a described predictive model for de novo SUI and to assess its clinical performance when used as a diagnostic test. Methods: This was a retrospective descriptive study on a cohort of consecutive women treated in our institution. The main outcome used to validate the model was the presence of objective or subjective SUI 1 year after surgery. A receiver operating characteristic curve was generated from our population to evaluate the predictive accuracy and to compare it with the original model. A cutoff point of ≥50% was used to evaluate its clinical performance as a diagnostic test. Results: Of the full cohort, 169 women were suitable for analysis. The rate of de novo SUI was 11.8%. The predictive accuracy of the model in our population was similar to the original [area under the curve (AUC) = 0.69; 95% confidence interval (CI) = 0.58–0.80). However, its performance measures when evaluated as a diagnostic test were low: positive likelihood ratio = 2.71 and negative likelihood ratio = 0.86. Only 15 women presented a positive test result. Conclusions: External validation of the model found a global predictive accuracy similar to that of the original model. Despite the study being underpowered to give firm conclusions, the test did not show a good clinical performance when applied to our population with low de novo SUI prevalence. A larger sample size is needed to validate the model conclusively.
AB - © 2018, The International Urogynecological Association. Introduction and hypothesis: Stress urinary incontinence (SUI) may appear after the correction of pelvic organ prolapse (POP). The aim of this study was to externally validate a described predictive model for de novo SUI and to assess its clinical performance when used as a diagnostic test. Methods: This was a retrospective descriptive study on a cohort of consecutive women treated in our institution. The main outcome used to validate the model was the presence of objective or subjective SUI 1 year after surgery. A receiver operating characteristic curve was generated from our population to evaluate the predictive accuracy and to compare it with the original model. A cutoff point of ≥50% was used to evaluate its clinical performance as a diagnostic test. Results: Of the full cohort, 169 women were suitable for analysis. The rate of de novo SUI was 11.8%. The predictive accuracy of the model in our population was similar to the original [area under the curve (AUC) = 0.69; 95% confidence interval (CI) = 0.58–0.80). However, its performance measures when evaluated as a diagnostic test were low: positive likelihood ratio = 2.71 and negative likelihood ratio = 0.86. Only 15 women presented a positive test result. Conclusions: External validation of the model found a global predictive accuracy similar to that of the original model. Despite the study being underpowered to give firm conclusions, the test did not show a good clinical performance when applied to our population with low de novo SUI prevalence. A larger sample size is needed to validate the model conclusively.
KW - De novo incontinence
KW - External validation
KW - Model performance
KW - Pelvic organ prolapse
KW - Predictive model
KW - Stress urinary incontinence
U2 - 10.1007/s00192-018-3805-1
DO - 10.1007/s00192-018-3805-1
M3 - Article
C2 - 30443760
VL - 30
SP - 1719
EP - 1723
JO - International Urogynecology Journal
JF - International Urogynecology Journal
SN - 0937-3462
ER -