Extending long-range heteronuclear NMR connectivities by HSQMBC-COSY and HSQMBC-TOCSY experiments

Josep Saurí, Núria Marcó, R. Thomas Williamson, Gary E. Martin, Teodor Parella

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    13 Citations (Scopus)

    Abstract

    © 2015 Elsevier Inc. Abstract The detection of long-range heteronuclear correlations presenting J(CH) coupling values smaller than 1-2 Hz is a challenge in the structural analysis of small molecules and natural products. HSQMBC-COSY and HSQMBC-TOCSY pulse schemes are evaluated as complementary NMR methods to standard HMBC/HSQMBC experiments. Incorporation of an additional J(HH) transfer step in the basic HSQMBC pulse scheme can favor the sensitive observation of traditionally missing or very weak correlations and, in addition, facilitates the detection of a significant number of still longer-range connectivities to both protonated and non-protonated carbons under optimum sensitivity conditions. A comparative 1H-13C study is performed using strychnine as a model compound and several examples are also provided including 1H-15N applications.
    Original languageEnglish
    Article number5663
    Pages (from-to)25-32
    JournalJournal of Magnetic Resonance
    Volume258
    DOIs
    Publication statusPublished - 8 Jul 2015

    Keywords

    • Heteronuclear coupling constants
    • HSQC-TOCSY
    • HSQMBC
    • HSQMBC-COSY
    • HSQMBC-TOCSY
    • Long-range correlations
    • LR-HSQMBC

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