Expression of the Pasteurella multocida ompH gene is negatively regulated by the Fur protein

Montserrat Bosch, Raul Tarragó, Ma Elena Garrido, Susana Campoy, Antonio R. Fernández de Henestrosa, Ana M. Pérez de Rozas, Ignacio Badiola, Jordi Barbé

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22 Citations (Scopus)


The fur gene of Pasteurella multocida has been cloned by complementation of an Escherichia coli fur mutant. The P. multocida fur gene, which encodes a predicted protein of 147 amino acids, displaying the highest identity (89%) with the same protein of Haemophilus influenzae, is negatively regulated by its own product. By construction of a P. multocida fur mutant, it has been demonstrated that the ompH gene, encoding a major structural protein of the outer membrane, presenting high antigenicity power, is negatively regulated by iron and glucose. Furthermore, wild-type and fur-defective cells of P. multocida show the same level of virulence. © 2001 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Original languageEnglish
Pages (from-to)35-40
JournalFEMS Microbiology Letters
Issue number1
Publication statusPublished - 11 Sept 2001


  • Catabolite repression
  • Fur and ompH genes
  • Pasteurella multocida
  • Virulence


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