Expression of p27/Kip1 is down-regulated in human prostate carcinoma progression

PL Fernandez, Y Arce, M. Farre, A Martinez, A Nadal, MJ Rey, N Peiro, E Campo, A Cardesa

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Abstract

p27(Kip1) is a cyclin-dependent kinase inhibitor whose down-regulation has been observed in several tumour models, including breast, colorectal, and gastric carcinomas. The purpose of this study was to assess p27(Kip1) protein expression in normal and benign prostatic epithelia as well as the possible existence of abnormalities in prostate carcinoma progression. p27(Kip1) expression was immunohistochemically analysed in 51 normal tissue samples, 11 nodular hyperplasias (NH), 22 high-grade prostatic intraepithelial neoplasias (PIN), 56 localized prostate adenocarcinomas, and 19 metastases. Immunoblotting was performed in ten cases. Normal prostate epithelium and NH showed diffuse and intense p27(Kip1) nuclear expression in most cases. A significant p27(Kip1) down-regulation was observed in many carcinomas when compared with benign epithelium, Forty-seven cases (84 per cent) mere low p27(Kip1) expressors (

Original languageEnglish
Pages (from-to)563-566
Number of pages4
JournalJ. Pathol.
Volume187
Issue number5
DOIs
Publication statusPublished - Apr 1999

Keywords

  • prostate cancer
  • prostate intraepithelial neoplasia
  • anti-oncogene
  • PIN
  • p27
  • Kip1
  • KINASE INHIBITOR P27(KIP1)
  • CELL-CYCLE
  • BREAST-CANCER
  • MOLECULAR ANALYSIS
  • MICE LACKING
  • P27
  • TUMORS
  • GENE
  • P21(WAF1/CIP1)
  • DEGRADATION

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