Expression of folate-sensitive fragile sites in lymphocyte chromosomes

Carme Fuster, Rosa Miró, Cristina Templado, Leonardo Barrios, Josep Egozcue

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15 Citations (Scopus)


The expression of folate-sensitive fragile sites (FS) was analyzed using MTX as a fragility inducer in seven normal subjects [four unrelated persons and three members of one family (father, mother, and son)]; a woman heterozygous for fra Xq27.3 with a 47,XXX karyotype; and her son, affected by the fra-X syndrome. The mean expression of chromosome lesions (CL) other than Xq27.3 was 70.1% (686CL in 978 metaphases), and the coincidence between CL and FS was 68.9%. We propose six new c-fra sites: bands 4q33 and 11q22 because they were found in two members of the same family; band 13q32 because it had a frequency of expression of 3% of metaphases; and bands 3p13, 8q21, and Xq21 because they were observed in four of the nine individuals studied. © 1989 Springer-Verlag.
Original languageEnglish
Pages (from-to)243-246
JournalHuman Genetics
Issue number3
Publication statusPublished - 1 Feb 1989


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