Abstract
The expression of receptor for androgen (AR), oestrogen α and β (ERα and ERβ) and progesterone (PR) was examined immunohistochemically in canine prostate specimens (normal, hyperplastic, inflamed [prostatitis] or neoplastic). AR immunolabelling was seen in 100% of epithelial cells of normal and hyperplastic tissue, the corresponding figures for inflamed and carcinomatous tissue being 74% and 65%, respectively. ERα labelling was seen in 85% of epithelial cells in normal prostate glands, the corresponding figures for hyperplastic, inflamed and neoplastic glands being 35%, 22% and 12%, respectively. ERβ labelling was seen in 85% of epithelial cells of normal glands and in about 70% of such cells in glands showing pathological changes. On the other hand, PR expression (weak) in normal glands was observed in fewer epithelial cells (44%) than in hyperplastic (70%), inflamed (62%) or neoplastic (64%) glands. © 2006 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Journal | Journal of Comparative Pathology |
| Volume | 136 |
| DOIs | |
| Publication status | Published - 1 Jan 2007 |
Keywords
- carcinoma
- dog
- hyperplasia
- prostate
- steroid receptors
- tumour
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Gallardo, F., Mogas, T., Baró, T., Rabanal, R., Morote, J., Abal, M., Reventós, J., & Lloreta, J. (2007). Expression of Androgen, Oestrogen α and β, and Progesterone Receptors in the Canine Prostate: Differences between Normal, Inflamed, Hyperplastic and Neoplastic Glands. Journal of Comparative Pathology, 136, 1-8. https://doi.org/10.1016/j.jcpa.2006.08.007