Expression of a possible constitutional "hot spot" in sperm chromosomes of a patient treated for Wilms' tumor

Anna Genescà; Rosa Miró; M. Rosa Caballin; Jordi Benet; Joaquima Navarro; Cristina Templado; Xavier Bonfill; Josep Egozcue

doi:10.1016/0165-4608(87)90034-3

Expression of a possible constitutional "hot spot" in sperm chromosomes of a patient treated for Wilms' tumor

Anna Genescà, Rosa Miró, M. Rosa Caballin, Jordi Benet, Joaquima Navarro, Cristina Templado, Xavier Bonfill, Josep Egozcue

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Abstract

Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells. © 1987.

Original language	English
Pages (from-to)	91-96
Journal	Cancer Genetics and Cytogenetics
Volume	29
DOIs	https://doi.org/10.1016/0165-4608(87)90034-3
Publication status	Published - 1 Jan 1987

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title = "Expression of a possible constitutional {"}hot spot{"} in sperm chromosomes of a patient treated for Wilms' tumor",

abstract = "Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells. {\textcopyright} 1987.",

author = "Anna Genesc{\`a} and Rosa Mir{\'o} and {Rosa Caballin}, M. and Jordi Benet and Joaquima Navarro and Cristina Templado and Xavier Bonfill and Josep Egozcue",

year = "1987",

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doi = "10.1016/0165-4608(87)90034-3",

language = "English",

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TY - JOUR

T1 - Expression of a possible constitutional "hot spot" in sperm chromosomes of a patient treated for Wilms' tumor

AU - Genescà, Anna

AU - Miró, Rosa

AU - Rosa Caballin, M.

AU - Benet, Jordi

AU - Navarro, Joaquima

AU - Templado, Cristina

AU - Bonfill, Xavier

AU - Egozcue, Josep

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells. © 1987.

AB - Sperm chromosomes were studied in a man who was treated for Wilms' tumor with radiotherapy (RT) and chemotherapy (CT) 18 years ago. Human pronuclear sperm chromosomes were obtained after penetration of zona-free hamster eggs. Eighty-nine sperm chromosome complements were analyzed; 12.4% of them showed structural anomalies. This percentage was statistically different from the one found in our laboratory for controls (p<0.05). Five of eleven structurally abnormal metaphases had the same aberration: fission of chromosome #1 with the breakpoint at or near the centromere. Breaks and rearrangements of chromosome #1, often involving the centromere region, are among the most frequent anomalies found in Wilms' tumor cells. © 1987.

U2 - 10.1016/0165-4608(87)90034-3

DO - 10.1016/0165-4608(87)90034-3

M3 - Article

SN - 0165-4608

VL - 29

SP - 91

EP - 96

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

ER -

Expression of a possible constitutional "hot spot" in sperm chromosomes of a patient treated for Wilms' tumor

Abstract

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