Exploring the risks of a putative transmission of BSE to new species

Enric Vidal, Natalia Fernández-Borges, Belén Pintado, Montserrat Ordóñez, Mercedes Márquez, Dolors Fondevila, Hasier Eraña, Juan María Torres, Martí Pumarola, Joaquín Castilla*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

The prion responsible for the Bovine Spongiform Encephalopathy (BSE) shows unique features when compared with other prions. One of these features is its ability to infect almost all experimentally tested animal models. In the paper published in The Journal of Neuroscience1 we describe a series of experiments directed toward elucidating which would be the in vivo behavior of BSE if it would infect dogs and rabbits, two alleged prion resistant species. Protein misfolding cyclic amplification (PMCA) was used to generate canidae and leporidae in vitro adapted BSE prions. A characterization of their in vivo pathobiological properties showed that BSE prions were capable not only of adapting to new species but they maintained, in the case of rabbits, their ability to infect transgenic mice expressing human PrP. The remarkable adaptation ability of certain prions implies that any new host species could lead to the emergence of new infectious agents with unpredictable transmission potential. Our results suggest that caution must be taken when considering the use of any mammal-derived protein in feedstuffs.

Original languageAmerican English
Pages (from-to)443-446
Number of pages4
JournalPrion
Volume7
Issue number6
DOIs
Publication statusPublished - Nov 2013

Keywords

  • BSE
  • PMCA
  • Prion
  • Prion resistant species
  • Scrapie
  • Transmission barrier

Fingerprint Dive into the research topics of 'Exploring the risks of a putative transmission of BSE to new species'. Together they form a unique fingerprint.

Cite this