Expansion of a CD26<sup>low</sup> effector t<inf>h</inf> subset and reduction in circulating levels of sCD26 in stable allergic asthma in adults

J. J. Nieto-Fontarigo, Francisco Javier González-Barcala, M. E. San-José, M. J. Cruz, T. Linares, M. T. Soto-Mera, L. Valdés-Cuadrado, M. A. García-González, L. J. Andrade-Bulos, P. Arias, M. Nogueira, F. J. Salgado

    Research output: Contribution to journalArticleResearchpeer-review

    7 Citations (Scopus)


    © 2018 Esmon Publicidad. Background: The pathogenesis of asthma is dependent on the balance between regulatory and effector T cells, which display differential expression of CD25 and CD26. Therefore, alteration of circulating levels of sCD25 and sCD26 during allergic asthma could be conditioned by changes in leukocyte phenotype. Objectives: To analyze expression of CD25 and CD26 on T lymphocytes and their soluble derivatives (sCD25, sCD26) during stable phases of moderate-severe allergic asthma. Methods: Cross-sectional study with 2 adult cohorts of allergic asthmatics. Clinical, anthropometric, pulmonary, hematological, and biochemical parameters were measured. Phenotyping was performed with flow cytometry in both circulating and cultured leukocytes. Dipeptidyl peptidase 4 (DPP4) activity was assayed in culture supernatants. Results: In vitro studies revealed upregulation of CD26 on human T lymphocytes upon activation, especially under TH17-favoring conditions, and a correlation with soluble DPP4 activity (rs=0.641; P<.001). CD26 expression on lymphocytes was higher in asthmatics, while serum sCD26 was lower in women and patients. The latter finding could be associated with an expanded CD25low/CD26low/CD127low subset of effector CD4+ T cells in allergic asthma, with no changes in Treg percentages. However, women showed an increased Teff/Treg ratio, which could explain their greater susceptibility to asthma. Conclusions: Allergic asthma causes an increment in CD25lowCD26low helper T cells detected in stable stages. These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α).
    Original languageEnglish
    Pages (from-to)113-125
    JournalJournal of Investigational Allergology and Clinical Immunology
    Issue number2
    Publication statusPublished - 1 Jan 2018


    • Asthma biomarkers
    • CD25
    • CD26
    • DPP4
    • Helper T cells
    • Lymphocytes


    Dive into the research topics of 'Expansion of a CD26<sup>low</sup> effector t<inf>h</inf> subset and reduction in circulating levels of sCD26 in stable allergic asthma in adults'. Together they form a unique fingerprint.

    Cite this