Exocrine pancreatic cancer clinical factors were related to timing of blood extraction and influenced serum concentrations of lipids

Miquel Porta, Olga Ferrer-Armengou, José Pumarega, Tomàs López, Marta Crous-Bou, Juan Alguacil, Montserrat Fitó, Manuel Jariod, Ángel Vicente, Eva Morales, María Isabel Covas, Elisa Puigdomènech, Nikhil Gupta

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Abstract

Objective: Disease-induced changes in blood concentrations of lipids may bias etiologic studies. We analyzed the influence of clinical factors and timing of blood extraction on serum concentrations of cholesterol and triglycerides in exocrine pancreatic cancer (EPC). Study Design and Setting: Subjects were 144 incident cases of EPC prospectively recruited in five teaching hospitals in eastern Spain. Results: Higher concentrations of cholesterol, triglycerides, and total lipids were observed among patients with a shorter interval from first symptom of cancer to blood extraction (IES); but concentrations were lower in patients with longer IES. The relationship between cholesterol and tumor stage was "n-shaped." Jaundice and other components of the cholestatic syndrome increased cholesterol and triglycerides. Invasive diagnostic tests were associated with lower cholesterol. All these factors were related to changes >50 mg/dl in cholesterol (P < 0.05), even when adjusting by stage. Statistical models including IES, number of invasive diagnostic tests, jaundice, weight loss, and stage explained over 28% of the variation in lipid concentrations. Conclusion: Restriction and adjustment by stage may be insufficient to prevent biases related to disease progression. Multivariate analyses may allow to control to some extent the influence of clinical symptoms, procedures, and timing of blood extraction in studies on the etiological significance of lipids and lipophilic compounds, either risk factors or protective agents. © 2008 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)695-704
JournalJournal of Clinical Epidemiology
Volume61
Issue number7
DOIs
Publication statusPublished - 1 Jul 2008

Keywords

  • Blood extraction
  • Cholesterol
  • Epidemiology, molecular
  • Jaundice
  • Lipids/blood
  • Lipophilic biomarkers
  • Pancreatic neoplasms
  • Research design/organization and administration
  • Symptoms
  • Total lipids
  • Triglycerides
  • Weight loss

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