Exercise and preexercise nutrition as treatment for McArdle disease

Gisela Nogales-Gadea, Alfredo Santalla, Alfonsina Ballester-Lopez, Joaquín Arenas, Miguel Angel Martín, Richard Godfrey, Tomàs Pinís, Guillem Pintos-Morell, Jaume Coll-Cantí, Alejandro Lucia

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

© 2016 by the American College of Sports Medicine. McArdle disease is due to an inborn defect in the muscle isoform of glycogen phosphorylase (or "myophosphorylase"), the enzyme that catalyzes the first step of glycogenolysis. This condition is still not fully understood, and although advances in research would help patients immeasurably, these would also enhance our understanding of exercise metabolism. It has been 10 yr since the first published report demonstrating the benefits of regular aerobic exercise for these patients. However, misconceptions remain and the value of exercise prescription for patients with McArdle disease is still overlooked. Here, we review the role of exercise in McArdle disease with the aim to better inform health-care professionals and thus better serve the interests of patients. Recommendations for regular exercise together with preexercise nutrition in children and adult patients are also provided along with examples of exercise practice and its benefits.
Original languageEnglish
Pages (from-to)673-679
JournalMedicine and Science in Sports and Exercise
Volume48
Issue number4
DOIs
Publication statusPublished - 1 Apr 2016

Keywords

  • ACTIVE LIFESTYLE
  • DIETARY RECOMMENDATIONS
  • EXERCISE THERAPY
  • GLYCOGENOSIS TYPE V
  • TRAINING

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