Evolutionary escape on complex genotype-phenotype networks

Esther Ibáñez-Marcelo, Tomás Alarcón

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    © 2016 Elsevier Ltd. We study the problem of evolutionary escape that is the process whereby a population under sudden changes in the selective pressures acting upon it try to evade extinction by evolving from previously well-adapted phenotypes to those that are favoured by the new selective pressure. We perform a comparative analysis between results obtained by modelling genotype space as a regular hypercube (H-graphs), which is the scenario considered in previous work on the subject, to those corresponding to a complex genotype-phenotype network (B-graphs). In order to analyse the properties of the escape process on both these graphs, we apply a general theory based on multi-type branching processes to compute the evolutionary dynamics and probability of escape. We show that the distribution of distances between phenotypes in B-graphs exhibits a much larger degree of heterogeneity than in H-graphs. This property, one of the main structural differences between both types of graphs, causes heterogeneous behaviour in all results associated to the escape problem. We further show that, due to the heterogeneity characterising escape on B-graphs, escape probability can be underestimated by assuming a regular hypercube genotype network, even if we compare phenotypes at the same distance in H-graphs. Similarly, it appears that the complex structure of B-graphs slows down the rate of escape.
    Original languageEnglish
    Pages (from-to)18-31
    JournalJournal of Theoretical Biology
    Volume394
    DOIs
    Publication statusPublished - 7 Apr 2016

    Keywords

    • Escape
    • Genotype-phenotype map
    • Resistance

    Fingerprint Dive into the research topics of 'Evolutionary escape on complex genotype-phenotype networks'. Together they form a unique fingerprint.

    Cite this