Evolution of genes and genomes on the Drosophila phylogeny

Andrew G. Clark, Michael B. Eisen, Douglas R. Smith, Casey M. Bergman, Brian Oliver, Therese A. Markow, Thomas C. Kaufman, Manolis Kellis, William Gelbart, Venky N. Iyer, Daniel A. Pollard, Timothy B. Sackton, Amanda M. Larracuente, Nadia D. Singh, Jose P. Abad, Dawn N. Abt, Boris Adryan, Montserrat Aguade, Hiroshi Akashi, Wyatt W. AndersonCharles F. Aquadro, David H. Ardell, Roman Arguello, Carlo G. Artieri, Daniel A. Barbash, Daniel Barker, Paolo Barsanti, Phil Batterham, Serafim Batzoglou, Dave Begun, Arjun Bhutkar, Enrico Blanco, Stephanie A. Bosak, Robert K. Bradley, Adrianne D. Brand, Michael R. Brent, Angela N. Brooks, Randall H. Brown, Roger K. Butlin, Corrado Caggese, Brian R. Calvi, A. Bernardo De Carvalho, Anat Caspi, Sergio Castrezana, Susan E. Celniker, Jean L. Chang, Charles Chapple, Sourav Chatterji, Asif Chinwalla, Alberto Civetta, Sandra W. Clifton, Josep M. Comeron, James C. Costello, Jerry A. Coyne, Jennifer Daub, Robert G. David, Arthur L. Delcher, Kim Delehaunty, Chuong B. Do, Heather Ebling, Kevin Edwards, Thomas Eickbush, Jay D. Evans, Alan Filipski, Sven Findeiß, Eva Freyhult, Lucinda Fulton, Robert Fulton, Ana C.L. Garcia, Anastasia Gardiner, David A. Garfield, Barry E. Garvin, Greg Gibson, Don Gilbert, Sante Gnerre, Jennifer Godfrey, Robert Good, Valer Gotea, Brenton Gravely, Anthony J. Greenberg, Sam Griffiths-Jones, Samuel Gross, Roderic Guigo, Erik A. Gustafson, Wilfried Haerty, Matthew W. Hahn, Daniel L. Halligan, Aaron L. Halpern, Gillian M. Halter, Mira V. Han, Andreas Heger, La Deana Hillier, Angie S. Hinrichs, Ian Holmes, Roger A. Hoskins, Melissa J. Hubisz, Dan Hultmark, Melanie A. Huntley, David B. Jaffe, Santosh Jagadeeshan, Marta Puig Font, Alfredo Ruiz Panadero

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1324 Citations (Scopus)

Abstract

Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of 12 Drosophila species, ten of which are presented here for the first time (sechellia, simulans, yakuba, erecta, ananassae, persimilis, willistoni, mojavensis, virilis and grimshawi), illustrate how rates and patterns of sequence divergence across taxa can illuminate evolutionary processes on a genomic scale. These genome sequences augment the formidable genetic tools that have made Drosophila melanogaster a pre-eminent model for animal genetics, and will further catalyse fundamental research on mechanisms of development, cell biology, genetics, disease, neurobiology, behaviour, physiology and evolution. Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. These may prove to underlie differences in the ecology and behaviour of these diverse species. ©2007 Nature Publishing Group.
Original languageEnglish
Pages (from-to)203-218
JournalNature
Volume450
DOIs
Publication statusPublished - 8 Nov 2007

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    Clark, A. G., Eisen, M. B., Smith, D. R., Bergman, C. M., Oliver, B., Markow, T. A., Kaufman, T. C., Kellis, M., Gelbart, W., Iyer, V. N., Pollard, D. A., Sackton, T. B., Larracuente, A. M., Singh, N. D., Abad, J. P., Abt, D. N., Adryan, B., Aguade, M., Akashi, H., ... Ruiz Panadero, A. (2007). Evolution of genes and genomes on the Drosophila phylogeny. Nature, 450, 203-218. https://doi.org/10.1038/nature06341