TY - JOUR
T1 - Evidence of inhaled tobramycin in non-cystic fibrosis bronchiectasis
AU - Vendrell, Montserrat
AU - Muñoz1mvendrell, Gerard
AU - De Gracia, Javier
PY - 2015/1/1
Y1 - 2015/1/1
N2 - © Vendrell et al.; Licensee Bentham Open. There is currently less experience with inhaled tobramycin in non-cystic fibrosis bronchiectasis than in cystic fibrosis (CF). Intravenous formulation and solution for inhalation (TSI) have been studied in non-CF bronchiectasis patients with chronic P. aeruginosa bronchial infection. An improvement in clinical parameters and a reduction in bacterial density have been shown with both inhaled solutions in these patients. However, further trials are needed to determine the most effective dose and administration protocol in these patients. Based on the current evidence, recommendations cannot be made regarding the use of TSI to treat exacerbations. Although no systemic toxicity has been reported in studies specifically investigating this treatment, patients with known kidney disease or ear disorders should be treated with caution. Adverse respiratory effects are reported to be more common in non-CF patients than in CF patients, who tend to be non-smokers and younger. Research is being conducted into the possibility of combining tobramycin with other antibiotics to increase its antibacterial activity. In this review we will present and discuss the published evidence regarding the use of inhaled tobramycin in non CF bronchiectasis.
AB - © Vendrell et al.; Licensee Bentham Open. There is currently less experience with inhaled tobramycin in non-cystic fibrosis bronchiectasis than in cystic fibrosis (CF). Intravenous formulation and solution for inhalation (TSI) have been studied in non-CF bronchiectasis patients with chronic P. aeruginosa bronchial infection. An improvement in clinical parameters and a reduction in bacterial density have been shown with both inhaled solutions in these patients. However, further trials are needed to determine the most effective dose and administration protocol in these patients. Based on the current evidence, recommendations cannot be made regarding the use of TSI to treat exacerbations. Although no systemic toxicity has been reported in studies specifically investigating this treatment, patients with known kidney disease or ear disorders should be treated with caution. Adverse respiratory effects are reported to be more common in non-CF patients than in CF patients, who tend to be non-smokers and younger. Research is being conducted into the possibility of combining tobramycin with other antibiotics to increase its antibacterial activity. In this review we will present and discuss the published evidence regarding the use of inhaled tobramycin in non CF bronchiectasis.
KW - Bronchiectasis
KW - Inhaled
KW - Tobramycin
UR - https://ddd.uab.cat/record/185309
U2 - https://doi.org/10.2174/1874306401509010030
DO - https://doi.org/10.2174/1874306401509010030
M3 - Article
VL - 9
SP - 30
EP - 36
JO - Open Respiratory Medicine Journal
JF - Open Respiratory Medicine Journal
SN - 1874-3064
ER -