Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat

Antonio Armario; Octavi Martí; Amadeu Gavaldá; Asuncion López-Calderón

doi:https://doi.org/10.1016/0361-9230(93)90006-W

Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat

Antonio Armario, Octavi Martí, Amadeu Gavaldá, Asuncion López-Calderón

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Abstract

The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute Stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat. © 1993.

Original language	English
Pages (from-to)	29-31
Journal	Brain Research Bulletin
Volume	31
DOIs	https://doi.org/10.1016/0361-9230(93)90006-W
Publication status	Published - 1 Jan 1993

Keywords

Immobilization stress
LH
Restraint stress
Serotonin

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title = "Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat",

abstract = "The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute Stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat. {\textcopyright} 1993.",

keywords = "Immobilization stress, LH, Restraint stress, Serotonin",

author = "Antonio Armario and Octavi Mart{\'i} and Amadeu Gavald{\'a} and Asuncion L{\'o}pez-Calder{\'o}n",

year = "1993",

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T1 - Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat

AU - Armario, Antonio

AU - Martí, Octavi

AU - Gavaldá, Amadeu

AU - López-Calderón, Asuncion

PY - 1993/1/1

Y1 - 1993/1/1

N2 - The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute Stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat. © 1993.

AB - The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute Stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat. © 1993.

KW - Immobilization stress

KW - LH

KW - Restraint stress

KW - Serotonin

U2 - https://doi.org/10.1016/0361-9230(93)90006-W

DO - https://doi.org/10.1016/0361-9230(93)90006-W

M3 - Article

SN - 0361-9230

VL - 31

SP - 29

EP - 31

JO - Brain Research Bulletin

JF - Brain Research Bulletin

ER -

Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat

Abstract

Keywords

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