Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat

Antonio Armario, Octavi Martí, Amadeu Gavaldá, Asuncion López-Calderón

    Research output: Contribution to journalArticleResearchpeer-review

    14 Citations (Scopus)

    Abstract

    The influence of serotonin on luteinizing hormone (LH) release caused by exposure to two acute Stressors differing in their intensity (restraint in tubes and immobilization in woodboards) was studied in adult male rats. Inhibition of serotonin synthesis with p-chlorophenylalanine (PCPA) significantly abolished LH release caused by immobilization (IMO). Administration of the serotonin antagonists mianserine and methiothepin also eliminated LH release caused by IMO without altering basal LH levels. These data represent the first evidence that a classical neurotransmitter (serotonin) is involved in LH release caused by stress in the rat. © 1993.
    Original languageEnglish
    Pages (from-to)29-31
    JournalBrain Research Bulletin
    Volume31
    DOIs
    Publication statusPublished - 1 Jan 1993

    Keywords

    • Immobilization stress
    • LH
    • Restraint stress
    • Serotonin

    Fingerprint Dive into the research topics of 'Evidence for the involvement of serotonin in acute stress-induced release of luteinizing hormone in the male rat'. Together they form a unique fingerprint.

    Cite this