Evidence-based consensus recommendations to improve the quality of life in prostate cancer treatment

Francesc Casas, Josep María Borràs, Ferran Ferrer, Núria Guanyabens, Rafael Gutiérrez Del Pozo, Concha León, José López Torrecilla, Begoña Mellado, Joan Morote, Manel Puig, María José Ribal, Carme Ruscalleda, Agustí Serra, Valentí Valls, Almudena Zapatero

Research output: Contribution to journalReview articleResearchpeer-review

5 Citations (Scopus)


Introduction Prostate cancer (PC) is one of the tumours with the highest incidence in recent years. PC therapies have several adverse effects. A panel consensus recommendation has been made to prevent or ameliorate complications in PC treatment to improve quality of life. Material and methods Fifteen specialists have met to analyse the different toxicities associated with PC treatment. Each medical specialist performed a National Library of Medicine PubMed search citations searching about these secondary effects and his speciality from 1999 to 2009 to propose measures for their prevention/ amelioration. Results Surgery is associated with incontinence and impotence. Radiotherapy can produce acute, late urological and gastrointestinal toxicity. Brachytherapy can produce acute urinary retention. Chemotherapy is associated with haematotoxicity, peripheral neuropathy and diarrhoea, and hormone therapy can produce osteoporosis, metabolic syndrome, cognitive and muscular alterations, cardiotoxicity, etc. Conclusions Improvement in surgical techniques and technology (IMRT/IGRT) can prevent surgical and radiotherapeutic toxicity, respectively. Brachytherapy toxicity can be prevented with precise techniques to preserve the urethra. Chemotherapy toxicity can be prevented with personalised schedules of treatment and close follow-up of iatrogenia and hormone therapy toxicity can be prevented with close follow-up of possible secondary effects.
Original languageEnglish
Pages (from-to)346-355
JournalClinical and Translational Oncology
Issue number5
Publication statusPublished - 1 May 2010


  • Chemotherapy
  • Hormone Deprivation
  • Prostate cancer
  • Quality of life
  • Radiotherapy
  • Surgery
  • Toxicity


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