Evaluation of the metal-dependent cytotoxic behaviour of coordination compounds

Jordi Grau, Cristina Renau, Ana B. Caballero, Amparo Caubet, Marta Pockaj, Julia Lorenzo, Patrick Gamez

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

© 2018 The Royal Society of Chemistry. The [Cu(L)Cl2]2 and [Pt(L)Cl2] complexes were prepared from the simple Schiff-base ligand (E)-phenyl-N-((pyridin-2-yl)methylene)methanamine (L) and respectively, CuCl2 and cis-[PtCl2(DMSO)2]. DNA-interaction studies revealed that the copper complex most likely acts as a DNA cleaver whereas the platinum complex binds to the double helix. Remarkably, cell-viability experiments with HeLa, MCF7 and PC3 cells showed that [Cu(L)Cl2]2 is an efficient cytotoxic agent whereas [Pt(L)Cl2] is not toxic, illustrating the crucial role played by the nature of the metal ion in the corresponding biological activity.
Original languageEnglish
Pages (from-to)4902-4908
JournalDalton Transactions
Volume47
Issue number14
DOIs
Publication statusPublished - 1 Jan 2018

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