Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

A. Hernández; F. J. Belda; J. Domínguez; M. Gimenez; M. Caraballo; C. Ramil; V. Ausina; Juana Maria Lourdes Matas Andreu

doi:https://doi.org/10.1016/S0195-6701(96)90070-5

Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

A. Hernández, F. J. Belda, J. Domínguez, M. Gimenez, M. Caraballo, C. Ramil, V. Ausina, Juana Maria Lourdes Matas Andreu

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

Original language	English
Pages (from-to)	223-228
Journal	Journal of Hospital Infection
Volume	34
DOIs	https://doi.org/10.1016/S0195-6701(96)90070-5
Publication status	Published - 1 Jan 1996

Keywords

Disinfectant granules
HIV
Sodium dichloroisocyanurate
Solprogel

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

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title = "Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)",

abstract = "The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.",

keywords = "Disinfectant granules, HIV, Sodium dichloroisocyanurate, Solprogel",

author = "A. Hern{\'a}ndez and Belda, {F. J.} and J. Dom{\'i}nguez and M. Gimenez and M. Caraballo and C. Ramil and V. Ausina and {Matas Andreu}, {Juana Maria Lourdes}",

year = "1996",

month = jan,

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doi = "https://doi.org/10.1016/S0195-6701(96)90070-5",

language = "English",

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Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1). / Hernández, A.; Belda, F. J.; Domínguez, J.; Gimenez, M.; Caraballo, M.; Ramil, C.; Ausina, V.; Matas Andreu, Juana Maria Lourdes.

In: Journal of Hospital Infection, Vol. 34, 01.01.1996, p. 223-228.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

AU - Hernández, A.

AU - Belda, F. J.

AU - Domínguez, J.

AU - Gimenez, M.

AU - Caraballo, M.

AU - Ramil, C.

AU - Ausina, V.

AU - Matas Andreu, Juana Maria Lourdes

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

AB - The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.

KW - Disinfectant granules

KW - HIV

KW - Sodium dichloroisocyanurate

KW - Solprogel

U2 - https://doi.org/10.1016/S0195-6701(96)90070-5

DO - https://doi.org/10.1016/S0195-6701(96)90070-5

M3 - Article

VL - 34

SP - 223

EP - 228

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

ER -