Evaluation of the disinfectant effect of Solprogel against human immunodeficiency virus type 1 (HIV-1)

A. Hernández, F. J. Belda, J. Domínguez, M. Gimenez, M. Caraballo, C. Ramil, V. Ausina, Juana Maria Lourdes Matas Andreu

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2 Citations (Scopus)

Abstract

The antiviral activities of sodium dichloroisocyanurate (NaDCC) and a commercial product (Solprogel 2%) against human immunodeficiency virus type 1 (HIV-1) were investigated using a quantitative suspension test method. Solprogel is a compound that contains NaDCC and a biodegradable polymer of acrylic acid. Viral suspensions were prepared containing 3.2 x 106 tissue culture infective dose 50 (TCID50) in culture media. Syncytium formation in the MT-2 line and HIV antigen p24 on the supernatant of the cultures were used to determine viral titre. Results indicate that satisfactory disinfection (1000-fold reduction in 5 min) can be achieved using NaDCC and Solprogel at concentrations of 100 and 120ppm available chlorine, respectively.
Original languageEnglish
Pages (from-to)223-228
JournalJournal of Hospital Infection
Volume34
DOIs
Publication statusPublished - 1 Jan 1996

Keywords

  • Disinfectant granules
  • HIV
  • Sodium dichloroisocyanurate
  • Solprogel

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