Evaluation of the BacT/ALERT PZA kit in comparison with the BACTEC 460TB PZA for testing Mycobacterium tuberculosis susceptibility to pyrazinamide

Lina Marcela Aragón, Montserrat Garrigó, Carmen Moreno, Montserrat Español, Pere Coll

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Objectives: To compare the performance of the BacT/ALERT PZA kit (BioMerieux, Marcy l'Etoile, France) with the radiometric BACTEC 460TB PZA test (Becton-Dickinson method) for testing Mycobacterium tuberculosis susceptibility to pyrazinamide. Methods: A total of 50 M. tuberculosis strains were tested. Thirty of these strains had been previously considered pyrazinamide-susceptible and 20 pyrazinamide-resistant by BACTEC 460TB. Results: Final overall agreement was 100%. Time needed for the susceptibility test was 6.69 days for the BacT/ALERT PZA kit versus 8.07 days for the BACTEC 460TB PZA test. Conclusions: BacT/ALERT PZA test isan excellent alternative to BACTEC 460TB for pyrazinamide susceptibility testing. © The Author 2007. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.
Original languageEnglish
Pages (from-to)655-657
JournalJournal of Antimicrobial Chemotherapy
Volume60
Issue number3
DOIs
Publication statusPublished - 1 Sep 2007

Keywords

  • Resistance
  • Susceptibility testing
  • Tuberculosis

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