Evaluation of the anti-HIV activity of statins

Gemma Moncunill, Eugenia Negredo, Lluís Bosch, Jaume Vilarrasa, Myriam Witvrouw, Anuska Llano, Bonaventura Clotet, José A. Esté

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.
Original languageEnglish
Pages (from-to)1697-1700
JournalAIDS
Volume19
Issue number15
DOIs
Publication statusPublished - 14 Oct 2005

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