Evaluation of the anti-HIV activity of statins

Gemma Moncunill; Eugenia Negredo; Lluís Bosch; Jaume Vilarrasa; Myriam Witvrouw; Anuska Llano; Bonaventura Clotet; José A. Esté

doi:10.1097/01.aids.0000183517.60384.db

Evaluation of the anti-HIV activity of statins

Gemma Moncunill, Eugenia Negredo, Lluís Bosch, Jaume Vilarrasa, Myriam Witvrouw, Anuska Llano, Bonaventura Clotet, José A. Esté

Department of Medicine

Research output: Contribution to journal › Article › Research › peer-review

52 Citations (Scopus)

Abstract

Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.

Original language	English
Pages (from-to)	1697-1700
Journal	AIDS
Volume	19
Issue number	15
DOIs	https://doi.org/10.1097/01.aids.0000183517.60384.db
Publication status	Published - 14 Oct 2005

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10.1097/01.aids.0000183517.60384.db

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AU - Moncunill, Gemma

AU - Negredo, Eugenia

AU - Bosch, Lluís

AU - Vilarrasa, Jaume

AU - Witvrouw, Myriam

AU - Llano, Anuska

AU - Clotet, Bonaventura

AU - Esté, José A.

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AB - Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.

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DO - 10.1097/01.aids.0000183517.60384.db

M3 - Article

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ER -

Evaluation of the anti-HIV activity of statins

Abstract

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