Evaluation of Plasma Procalcitonin Concentrations in Healthy Foals and Foals Affected by Septic Systemic Inflammatory Response Syndrome

Francesca Bonelli, Valentina Meucci, Thomas Divers, Rolfe Radcliffe, Eduard Jose-Cunilleras, Michele Corazza, Grazia Guidi, Rosalba Tognetti, Carolina Castagnetti, Luigi Intorre, Micaela Sgorbini

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    Abstract

    © 2015 Elsevier Inc. The aim of this work was to evaluate procalcitonin (PCT) concentrations in healthy foals and in foals with septic systemic inflammatory response syndrome (SIRS). Plasma PCT concentrations were evaluated in 51 foals, and SIRS scale was calculated. Foals were divided into control group (no septic SIRS criteria met) and septic SIRS group (SIRS score ≥2 plus evidence of sepsis or localized infection). Procalcitonin concentrations were evaluated with a commercial ELISA kit. The data were expressed as mean and standard deviation. A t-test was performed between healthy and septic SIRS groups. A receiver operating characteristic (ROC) curve was carried out. Finally, correlation analysis between PCT concentration and SIRS scale was performed by using Pearson test. The PCT concentrations in control and septic SIRS groups were 30.0 ± 33.1 and 178.9 ± 76.0 pg/mL, respectively. The t-test showed differences between control group and septic SIRS group (P < .0001). A positive linear correlation between PCT concentration and SIRS scale was observed (r = 0.73; r<sup>2</sup> = 0.53; P < .0001). The ROC curve was statistically significant (P < .0001), and the best cutoff value to determine septic SIRS was 73.04 pg/mL (87.5% sensitivity, 97.1% specificity, and a likelihood ratio of 30.6). Overall, the results showed an increase in plasma PCT concentrations in septic SIRS foals. A cutoff between control and septic SIRS groups was obtained.
    Original languageEnglish
    Pages (from-to)645-649
    JournalJournal of Equine Veterinary Science
    Volume35
    Issue number8
    DOIs
    Publication statusPublished - 1 Jan 2015

    Keywords

    • Foal
    • Marker
    • Procalcitonin
    • Sepsis
    • Systemic inflammatory response syndrome

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  • Cite this

    Bonelli, F., Meucci, V., Divers, T., Radcliffe, R., Jose-Cunilleras, E., Corazza, M., Guidi, G., Tognetti, R., Castagnetti, C., Intorre, L., & Sgorbini, M. (2015). Evaluation of Plasma Procalcitonin Concentrations in Healthy Foals and Foals Affected by Septic Systemic Inflammatory Response Syndrome. Journal of Equine Veterinary Science, 35(8), 645-649. https://doi.org/10.1016/j.jevs.2015.06.007