Evaluation of four different fecal tests for determination of cure after Helicobacter pylori treatment

Mariela Quesada, Xavier Calvet, Angelina Dosal, Victoria Calvet, Isabel Sanfeliu, Laura Ribera, Theresa Choat, Barbara Fallowfield, Antònia Montserrat, Valentí Puig, Ferran Segura

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16 Citations (Scopus)

Abstract

BACKGROUND: Data evaluating the monoclonal tests for determination of cure after Helicobacter pylori treatment are scarce. GOALS: This study was aimed to evaluate the usefulness of 4 stool tests-2 new RAPID monoclonal immunochromatographic tests (RAPID Hp StAR, DakoCytomation, Cambridge, UK and ImmunoCard STAT! HpSA, Meridian Diagnostics, Cincinnati, OH) a monoclonal EIA test (Amplified IDEIA Hp StAR, DakoCytomation, Cambridge, UK), and a polyclonal EIA test (Premier Platinum HpSA, Meridian Diagnostics, Cincinnati, OH)-to confirm cure of H. pylori infection after eradication treatment. STUDY: Ninety-seven patients who underwent eradication treatment were included. Cure of H. pylori infection was determined using 2 consecutive reference tests. Fecal tests were performed according to the specifications of the manufacturer. Sensitivity, specificity, and positive and negative predictive values were calculated. RESULTS: After H. pylori eradication, the RAPID Hp StAR test has a sensitivity of 73% for detecting persistent infection, a specificity of 96% to 98%, a positive predictive value of 73% to 80% and a negative predictive value of 96%. For ImmunoCard STAT! HpSA the corresponding values were 91%, 97%, 77%, and 99%, for Amplified IDEIA Hp StAR 73%, 97%, 73%, and 97%, and for Premier Platinum HpSA 91%, 79%, 35%, and 98%. CONCLUSIONS: All tests except Premier Platinum HpSA were highly accurate confirming eradication after treatment. © 2006 Lippincott Williams & Wilkins, Inc.
Original languageEnglish
Pages (from-to)790-794
JournalJournal of Clinical Gastroenterology
Volume40
Issue number9
DOIs
Publication statusPublished - 1 Oct 2006

Keywords

  • Fecal tests
  • H. pylori treatment

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    Quesada, M., Calvet, X., Dosal, A., Calvet, V., Sanfeliu, I., Ribera, L., Choat, T., Fallowfield, B., Montserrat, A., Puig, V., & Segura, F. (2006). Evaluation of four different fecal tests for determination of cure after Helicobacter pylori treatment. Journal of Clinical Gastroenterology, 40(9), 790-794. https://doi.org/10.1097/01.mcg.0000225606.18234.38