Evaluation of direct and axon reflex sweating in the mouse

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The nicotinic axon reflex-mediated sudomotor response was studied in mice and rats by recording the impressions of sweat droplets made in silicone molds after local injection of nicotine, and compared with sweating induced by acetylcholine and pilocarpine. Nicotine failed to activate mouse plantar sweat glands at any of the concentrations used (from 3x10-6 to 3x10-1 M). On the contrary, both acetylcholine and pilocarpine produced a dose-dependent increase in the number of secreting sweat glands. The location of sweat glands reactive to pilocarpine and acetylcholine was similar and restricted to the pads near the site of injection. We conclude that the sudomotor axon reflex response mediated by nicotinic receptors is not present in the mouse and the rat. Copyright (C) 2000 Elsevier Science B.V.
Original languageEnglish
Pages (from-to)136-140
JournalJournal of the Autonomic Nervous System
Publication statusPublished - 14 Jan 2000


  • Cholinergic stimulation
  • Mouse
  • Nicotine
  • Sudomotor axon reflex
  • Sweat glands


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