Evaluation of C-reactive-like protein in Mytilus galloprovincialis

Lorena Franco-Martínez, Asta Tvarijonaviciute, Sandra V. Mateo, José J. Cerón, D. Romero, Miguel Oliveira, Mariana Teles, Silvia Martínez-Subiela

Research output: Contribution to journalArticleResearch


© 2019 Elsevier Ltd C-reactive protein (CRP) is an acute phase protein of the innate immune system with an important role as biomarker in many biological processes in mammals. However, there is a lack of information regarding CRP in molluscs and there is no data about the presence of CRP-like protein in mussels. In the present work, CPR-like protein was identified and purified from the digestive gland of the Mediterranean mussel Mytilus galloprovincialis. In addition, it was demonstrated that CRP-like protein can be measured accurately and precisely by a high-throughput automated method. Finally, higher levels of CRP-like protein in mussels exposed to hypoxia and nanoplastics were detected when compared to controls. The results obtained indicate that CRP-like protein could be a suitable novel biomarker of inflammatory response in mussels for biomonitoring programs being economic, easy and rapid to determine.
Original languageEnglish
Article number105537
JournalEcological Indicators
Publication statusPublished - 1 Nov 2019


  • Acute phase response
  • Biomonitoring
  • C-reactive protein
  • Hypoxia
  • Pollution


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