Ethyl pyruvate induces tolerogenic dendritic cells

Neda Djedovic, María José Mansilla, Bojan Jevtić, Juan Navarro-Barriuso, Tamara Saksida, Eva M. Martínez-Cáceres, Ðorđe Miljković

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4 Citations (Scopus)

Abstract

Copyright © 2019 Djedovic, Mansilla, Jevtić, Navarro-Barriuso, Saksida, Martínez-Cáceres and Miljković. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Dendritic cells (DC) are professional antigen presenting cells that have a key role in shaping the immune response. Tolerogenic DC (tolDC) have immuno-regulatory properties and they are a promising prospective therapy for multiple sclerosis and other autoimmune diseases. Ethyl pyruvate (EP) is a redox analog of dimethyl fumarate (Tecfidera), a drug for multiple sclerosis treatment. We have recently shown that EP ameliorates experimental autoimmune encephalomyelitis, a multiple sclerosis murine model. Here, we expanded our study to its tolerogenic effects on DC. Phenotypic analysis has shown that DC obtained from mice or humans reduce expression of molecules required for T cell activation such as CD86, CD83, and HLA-DR under the influence of EP, while CD11c expression and viability of DC are not affected. Furthermore, EP-treated DC restrain proliferation and modulate cytokine production of allogeneic lymphocytes. These results demonstrate that EP has the ability to direct DC toward tolDC.
Original languageEnglish
Article number157
JournalFrontiers in Immunology
Volume10
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Autoimmunity
  • Dendritic cells
  • Ethyl pyruvate
  • Immune-regulation
  • Tolerogenicity

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