Abstract
Synthetic approaches to bicyclic and tricyclic α,α‐disubstituted α‐amino acids and derivatives 6, 8, 10, 12, 13, 21, 22, 23, 24, 28, 30, and 31 are presented. Methyl acetoacetate, ethyl nitroacetate, and ethyl N‐(diphenylmethylene)glycinate are compared as anionic glycine equivalents. Palladium‐induced reductive couplings, Diels‐Alder and Pauson‐Khand reactions are used in the cyclisation steps. Copyright © 1995 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Original language | English |
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Pages (from-to) | 1807-1814 |
Journal | Liebigs Annalen |
Volume | 1995 |
Issue number | 10 |
DOIs | |
Publication status | Published - 22 Sep 1995 |
Keywords
- Anionic glycine equivalent
- Ethyl N‐(diphenylmethylene)glycinate
- Palladium‐induced reductive coupling
- Pauson‐Khand reaction
- Phase‐transfer catalysis