Ethyl N‐(diphenylmethylene)glycinate as anionic glycine equivalent transition metal mediated preparation of bicyclic and tricyclic α,α‐disubstituted α‐amino acids and derivatives

Marcial Moreno‐Mañas, Roser Pleixats, Anna Roglans

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17 Citations (Scopus)

Abstract

Synthetic approaches to bicyclic and tricyclic α,α‐disubstituted α‐amino acids and derivatives 6, 8, 10, 12, 13, 21, 22, 23, 24, 28, 30, and 31 are presented. Methyl acetoacetate, ethyl nitroacetate, and ethyl N‐(diphenylmethylene)glycinate are compared as anionic glycine equivalents. Palladium‐induced reductive couplings, Diels‐Alder and Pauson‐Khand reactions are used in the cyclisation steps. Copyright © 1995 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Original languageEnglish
Pages (from-to)1807-1814
JournalLiebigs Annalen
Volume1995
Issue number10
DOIs
Publication statusPublished - 22 Sep 1995

Keywords

  • Anionic glycine equivalent
  • Ethyl N‐(diphenylmethylene)glycinate
  • Palladium‐induced reductive coupling
  • Pauson‐Khand reaction
  • Phase‐transfer catalysis

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