Ethyl N-(diphenylmethylene)glycinate as anionic glycine equivalent. Monoalkylation, dialkylation and michael additions under solid-liquid phase-transfer catalysis

Anna López, Marcial Moreno-Mañas, Roser Pleixats, Anna Roglans, Jesús Ezquerra, Concepción Pedregal

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Ethyl N-(diphenylmethylene)glycinate, 1, undergoes monoalkylations, dialkylations and Michael additions to ethylenic and acetylenic acceptors under appropriate solid-liquid phase transfer catalysis conditions. Further transformations of the α-disubstituted ketimines lead to α-alkylated aspartic and glutamic acid derivatives 10, 15, 19 and 26, to bicyclic amino acids or derivatives featuring pyrazolone and isoxazolone moieties 30 and 33, and to α-substituted (E)-3,4-dehydroglutamic acids. Copyright © 1996 Elsevier Science Ltd.
Original languageEnglish
Pages (from-to)8365-8386
JournalTetrahedron
Volume52
Issue number24
DOIs
Publication statusPublished - 10 Jun 1996

Fingerprint Dive into the research topics of 'Ethyl N-(diphenylmethylene)glycinate as anionic glycine equivalent. Monoalkylation, dialkylation and michael additions under solid-liquid phase-transfer catalysis'. Together they form a unique fingerprint.

Cite this