TY - JOUR
T1 - Establishment and validation of a dose-effect curve for γ-rays by cytogenetic analysis
AU - Barquinero, Joan Francesc
AU - Barrios, Leonardo
AU - Caballín, Maria Rosa
AU - Miró, Rosa
AU - Ribas, Montserrat
AU - Subias, Antoni
AU - Egozcue, Josep
PY - 1995/1/1
Y1 - 1995/1/1
N2 - A dose-effect curve obtained by analysis of dicentric chromosomes after irradiation of peripheral blood samples, from one donor, at 11 different doses of γ-rays is presented. For the elaboration of this curve, more than 18 000 first division metaphases have been analyzed. The results fit very well to the linear-quadratic model. To validate the curve, samples from six individuals (three controls and three occupationally exposed persons) were irradiated at 2 Gy. The results obtained, when compared with the curve, showed that in all cases the 95% confidence interval included the 2 Gy dose, with estimated dose ranges from 1.82 to 2.19 Gy. © 1995.
AB - A dose-effect curve obtained by analysis of dicentric chromosomes after irradiation of peripheral blood samples, from one donor, at 11 different doses of γ-rays is presented. For the elaboration of this curve, more than 18 000 first division metaphases have been analyzed. The results fit very well to the linear-quadratic model. To validate the curve, samples from six individuals (three controls and three occupationally exposed persons) were irradiated at 2 Gy. The results obtained, when compared with the curve, showed that in all cases the 95% confidence interval included the 2 Gy dose, with estimated dose ranges from 1.82 to 2.19 Gy. © 1995.
KW - Cytogenetic analysis
KW - Dose-effect curve
KW - Gamma-rays
U2 - https://doi.org/10.1016/0027-5107(94)00150-4
DO - https://doi.org/10.1016/0027-5107(94)00150-4
M3 - Article
SN - 0027-5107
VL - 326
SP - 65
EP - 69
JO - Mutation Research
JF - Mutation Research
ER -