Establishment and validation of a dose-effect curve for γ-rays by cytogenetic analysis

Joan Francesc Barquinero, Leonardo Barrios, Maria Rosa Caballín, Rosa Miró, Montserrat Ribas, Antoni Subias, Josep Egozcue

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Abstract

A dose-effect curve obtained by analysis of dicentric chromosomes after irradiation of peripheral blood samples, from one donor, at 11 different doses of γ-rays is presented. For the elaboration of this curve, more than 18 000 first division metaphases have been analyzed. The results fit very well to the linear-quadratic model. To validate the curve, samples from six individuals (three controls and three occupationally exposed persons) were irradiated at 2 Gy. The results obtained, when compared with the curve, showed that in all cases the 95% confidence interval included the 2 Gy dose, with estimated dose ranges from 1.82 to 2.19 Gy. © 1995.
Original languageEnglish
Pages (from-to)65-69
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume326
DOIs
Publication statusPublished - 1 Jan 1995

Keywords

  • Cytogenetic analysis
  • Dose-effect curve
  • Gamma-rays

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