EPR study of the interactions between dendrimers and peptides involved in Alzheimer's and prion diseases

Barbara Klajnert, Michela Cangiotti, Sara Calici, Jean Pierre Majoral, Anne Marie Caminade, Josep Cladera, Maria Bryszewska, Maria Francesca Ottaviani

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

Abstract

Spin-probe and spin-label techniques were used to study the interactions of the Aβ 1-28 peptide involved in Alzheimer disease and the PrP 106-126 peptide suspected to be preferentially involved in spongiform encephalopathies with three different types of dendrimers. A computer-aided EPR analysis of a positively charged and a neutral spin probe was performed by comparing the pure dendrimer and peptide systems with the dendrimer-peptide ones. Also spin-labeled PAMAM dendrimers were used to test the interactions. The results show the interactions between dendrimer and peptide monomer to be stronger for Aβ 1-28 than for PrP 106-126. PAMAM dendrimers perturb the aggregation of the peptides more than PPI dendrimers do. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.
Original languageEnglish
Pages (from-to)1065-1074
JournalMacromolecular Bioscience
Volume7
Issue number8
DOIs
Publication statusPublished - 7 Aug 2007

Keywords

  • Alzheimer's disease
  • Dendrimers
  • EPR
  • Prions

Fingerprint Dive into the research topics of 'EPR study of the interactions between dendrimers and peptides involved in Alzheimer's and prion diseases'. Together they form a unique fingerprint.

Cite this