Epithelioid malignant peripheral nerve sheath tumour in a dog

P. García*, B. Sánchez, A. Sánchez, M. González, E. Rollán, J. M. Flores

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    16 Citations (Scopus)


    An unusual morphological variant of malignant peripheral nerve sheath tumour, in which the cells exhibited a predominantly epithelial morphology, was diagnosed in a dog. The animal had a history of progressive ataxia. Post-mortem examination revealed an infiltrative growth in the sublumbar region, encroaching on the L1 and L2 vertebral bodies; additional masses were observed in the kidneys, liver and lungs. Histologically, the subcutaneous mass was composed of a dense population of spindle-shaped cells arranged in fascicles. The internal masses were composed of epithelioid cells arranged in a nodular pattern. Immunohistochemically, the spindle-shaped cells of the subcutaneous mass were positive for S-100, and the epithelioid cells of the internal growths exhibited weak S-100 immunoreactivity.

    Original languageEnglish
    Pages (from-to)87-91
    Number of pages5
    JournalJournal of Comparative Pathology
    Issue number1
    Publication statusPublished - Jul 2004


    • Dog
    • Malignant peripheral nerve sheath tumour
    • Tumour


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