Epilepsy in glioblastoma patients: Basic mechanisms and current problems in treatment

Jordi Bruna, Júlia Miró, Roser Velasco

Research output: Contribution to journalReview articleResearchpeer-review

19 Citations (Scopus)

Abstract

Glioblastoma-related epilepsy requires paying careful attention to a combination of factors with an integrated approach. Major interrelated issues must be considered in the seizure care of glioblastoma patients. Seizure control frequently requires the administration of antiepileptic drugs simultaneously with other treatments, including surgery, radiotherapy and chemotherapy, with complete seizure relief often being difficult to achieve. The pharmacological interactions between antiepileptic drugs and antineoplastic agents can modify the activity of both treatments, compromising their efficacy and increasing the probability of developing adverse events related to both therapies. This review summarizes the new pathophysiological pathways involved in the epileptogenesis of glioblastoma-related seizures and the interactions between antiepileptic drugs and oncological treatment, paying special attention to its impact on survival and the current evidence of the antiepileptic treatment efficacy, including the potential usefulness of new third-generation compounds. © 2013 Expert Reviews Ltd.
Original languageEnglish
Pages (from-to)333-344
JournalExpert Review of Clinical Pharmacology
Volume6
Issue number3
DOIs
Publication statusPublished - 1 May 2013

Keywords

  • high-grade glioma
  • prophylaxis
  • seizures

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